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Hydroxychloroquine

Name: Hydroxychloroquine
Brand: TargetMol
SKU: T9287
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T9287Cas No. 118-42-3

Alias 2-[[4-[(7-Chloroquinolin-4-yl)amino]pentyl](ethyl)amino]ethanol

Hydroxychloroquine (2-[[4-[(7-Chloroquinolin-4-yl)amino]pentyl](ethyl)amino]ethanol) (HCQ) is an alkalinizing lysosomatropic drug that acts by inducing apoptosis of renal cancer cells in vitro and inhibiting TLR7/9. It is a medication used to prevent and treat malaria, and it's also being studied as an experimental treatment for COVID-19.

Hydroxychloroquine

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Purity: 99.79%

Catalog No. T9287Alias 2-[[4-[(7-Chloroquinolin-4-yl)amino]pentyl](ethyl)amino]ethanolCas No. 118-42-3

Pack Size	Price	USA Warehouse	Global Warehouse
50 mg	$30	In Stock	In Stock
100 mg	$39	In Stock	In Stock
200 mg	$55	In Stock	In Stock
500 mg	$91	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.79%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR HPLC

Product Introduction

Hydroxychloroquine AI Summary

Hydroxychloroquine exhibits multifaceted bioactivities and pharmacokinetic properties. It is a modulator of Lamin A splicing with a potency of 35481.3 nM and acts as a delayed-death inhibitor of malaria parasite plastid with potencies of 169.4 nM and 151.0 nM after 96-hour and 48-hour incubations, respectively. The compound shows antiviral activities against SARS-CoV-2 and Dengue virus 2, with significant potency in inhibiting viral replication in Vero E6 and BHK-21 cells. It also inhibits SARS-CoV-2 3CL-Pro protease and Zika virus NS2B-NS3 protease. Moreover, Hydroxychloroquine has antagonistic effects on TLR7 and TLR9, and demonstrates cytotoxicity against various cell lines, including African green monkey Vero cells and human A549 cells. Pharmacokinetically, Hydroxychloroquine showcases a large volume of distribution (Vdss = 700.0 L.kg-1), a long half-life (T1/2 = 850.0 hr), and a mean residence time (MRT = 1300.0 hr). It has moderate plasma protein binding (Fu = 0.57) and a clearance rate of 11.0 mL.min-1.kg-1. Upon oral administration, it reaches Tmax in 2.4 hours with a Cmax of 1220.0 nM and an AUC value of 34360.52 ng.hr.mL-1. The compound exhibits moderate to severe hepatic side effects, such as hepatic failure with a high HepSE score and moderate liver toxicity during clinical trials. In terms of receptor binding, Hydroxychloroquine shows affinity for Alpha-1D adrenergic, Imidazoline I2, Muscarinic M2 receptors, and others, with varying IC50 values. Additionally, it has shown bioactivity in inhibiting human recombinant ACE2 and cGAS in THP-1 cells, with potent inhibitory effects on certain receptors, transporters, and enzymes. Overall, Hydroxychloroquine possesses diverse bioactivities across different biological targets and demonstrates significant pharmacokinetic and toxicological profiles, indicating its potential for various therapeutic applications and the necessity for cautious consideration of its side effect profile..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Hydroxychloroquine (2-[[4-[(7-Chloroquinolin-4-yl)amino]pentyl](ethyl)amino]ethanol) (HCQ) is an alkalinizing lysosomatropic drug that acts by inducing apoptosis of renal cancer cells in vitro and inhibiting TLR7/9. It is a medication used to prevent and treat malaria, and it's also being studied as an experimental treatment for COVID-19.
Synonyms	2-[[4-[(7-Chloroquinolin-4-yl)amino]pentyl](ethyl)amino]ethanol

Chemical Properties

Molecular Weight	335.87
Formula	C₁₈H₂₆ClN₃O
Cas No.	118-42-3
Smiles	CCN(CCO)CCCC(C)NC1=CC=NC2=CC(Cl)=CC=C12
Relative Density.	1.176 g/cm3

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 1.65 mg/mL (4.91 mM), Sonication and heating to 60℃ are recommended.

DMSO: 257 mg/mL (765.18 mM), Sonication is recommended.

1M HCl: 99 mg/mL (294.76 mM), when pH is adjusted to 2 with HCl.

Solution Preparation Table

H2O/1M HCl/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9773 mL	14.8867 mL	29.7734 mL	148.8671 mL

1M HCl/DMSO

	1mg	5mg	10mg	50mg
5 mM	0.5955 mL	2.9773 mL	5.9547 mL	29.7734 mL
10 mM	0.2977 mL	1.4887 mL	2.9773 mL	14.8867 mL
20 mM	0.1489 mL	0.7443 mL	1.4887 mL	7.4434 mL
50 mM	0.0595 mL	0.2977 mL	0.5955 mL	2.9773 mL
100 mM	0.0298 mL	0.1489 mL	0.2977 mL	1.4887 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc