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Nicotinamide riboside malate

Name: Nicotinamide riboside malate
Brand: TargetMol
SKU: T40060
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T40060 Copy Product Info

Purity: 99.87%

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Nicotinamide riboside malate is a compound formed by the salt of nicotinamide riboside and malic acid. Nicotinamide riboside malate acts as a precursor to NAD⁺ and promotes the elevation of NAD⁺ levels within cells by supplementing the NR pathway, thereby participating in energy metabolism and the regulation of mitochondrial function.

Nicotinamide riboside malate

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Catalog No. T40060

Cas No. 2415659-01-5

Pack Size	Price	USA Stock	Global Stock
50 mg	$31	-	In Stock
100 mg	$44	-	In Stock
500 mg	$71	-	In Stock
1 g	$93	-	In Stock
5 g	$228	-	In Stock
10 g	$338	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.87%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Nicotinamide riboside malate is a compound formed by the salt of nicotinamide riboside and malic acid. Nicotinamide riboside malate acts as a precursor to NAD⁺ and promotes the elevation of NAD⁺ levels within cells by supplementing the NR pathway, thereby participating in energy metabolism and the regulation of mitochondrial function.
In vitro	Nicotinamide riboside malate (0.5 nM; 24 hours) reduces the acetylation status of Ndufa9 and SOD2[1]. Nicotinamide riboside malate increases intracellular and mitochondrial NAD + content in C2C12, Hepa1.6, and HEK293 cells in a concentration-dependent manner at concentrations ranging from 1-1000 μM[1]. Nicotinamide riboside malate boosts NAD to restore antiviral poly(ADP-ribose) polymerase (PARP) functions to support innate immunity for coronavirus (CoVs), a cause of COVID-19[3]. Western Blot Analysis, Cell Line: HEK293T cells Concentration: 0.5 nM Incubation Time: 24 hours Result: Reduced the acetylation status of Ndufa9 and SOD2 [1].
In vivo	Chronic supplementation with Nicotinamide riboside malate (p.o.; 400 mg/kg/day; for 16 weeks) elevates plasma and intracellular NAD+ levels in a tissue-specific manner[1]. This effect was observed in a study conducted on 10-week-old C57Bl/6J mice administered orally with a daily dosage of 400 mg/kg for a period of 16 weeks, leading to an increase in both plasma and intracellular NAD+ content, highlighting the compound's potential for targeted therapeutic applications. Chronic Nicotinamide riboside malate (p.o.; 400 mg/kg/day; for 16 weeks) supplementation increases plasma and intracellular NAD + content in a tissue-specific manner[1].

Chemical Properties

Molecular Weight	388.33
Formula	C₁₅H₂₀N₂O₁₀
Cas No.	2415659-01-5
Smiles	O[C@H]1[C@@H](O[C@H](CO)[C@H]1O)[N+]=2C=C(C(N)=O)C=CC2.[C@H](CC([O-])=O)(C(O)=O)O

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 116.67 mg/mL (300.44 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	2.5751 mL	12.8756 mL	25.7513 mL	128.7565 mL
5 mM	0.5150 mL	2.5751 mL	5.1503 mL	25.7513 mL
10 mM	0.2575 mL	1.2876 mL	2.5751 mL	12.8756 mL
20 mM	0.1288 mL	0.6438 mL	1.2876 mL	6.4378 mL
50 mM	0.0515 mL	0.2575 mL	0.5150 mL	2.5751 mL
100 mM	0.0258 mL	0.1288 mL	0.2575 mL	1.2876 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc