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Sulfisoxazole

Name: Sulfisoxazole
Brand: TargetMol
SKU: T0750
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0750Cas No. 127-69-5

Alias Sulfafurazole, NU-445

Sulfisoxazole (Sulfafurazole) is a short-acting sulfonamide antibacterial with activity against a wide range of gram-negative and gram-positive organisms.Sulfisoxazole inhibits breast cancer exosome release by targeting endothelin receptor A.

Sulfisoxazole

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Purity: 99.98%

Catalog No. T0750Alias Sulfafurazole, NU-445Cas No. 127-69-5

Pack Size	Price	USA Warehouse	Global Warehouse
200 mg	$31	In Stock	In Stock
500 mg	$48	In Stock	In Stock
1 g	$68	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.98%

Appearance:Solid

Color:White

Resource Download

COA LCMS HPLC HNMR

Product Introduction

Sulfisoxazole AI Summary

Sulfisoxazole exhibits multifaceted bioactivity and pharmacokinetic properties, making it a significant compound for research. It shows potent inhibition of the Endothelin A receptor with an IC50 ranging from 780.0 nM to 9000.0 nM, indicating its strong interaction with this receptor in various systems, including rat aortic smooth muscle cells and human cells. Its binding affinity is much lower for the Endothelin B receptor, with an IC50 of 24000.0 nM. Pharmacokinetically, Sulfisoxazole has high oral bioavailability (>80%) and significant plasma protein binding in humans (91.28%), dogs (86.59%), and rats (98.47%). It demonstrates moderate clearance rates and distribution, with a total clearance of 0.3 mL.min-1.kg-1 and a volume of distribution at steady state of 0.17 L.kg-1. Its physicochemical properties include a logD6.5 value of -0.5 and a pKa of 5.0. Additionally, Sulfisoxazole exhibits bioactivity as an inhibitor of the Menin-MLL interaction, Thyroid Stimulating Hormone Receptor, Cytochrome P450 2C19, and various other targets. It shows antimicrobial activity against bacteria like Escherichia coli and Staphylococcus epidermidis, and antifungal activity against Aspergillus fumigatus, with MIC values indicating broad-spectrum bioactivity. Despite some liver toxicity and moderate liver clearance rates, it demonstrates low intrinsic clearance rates in rat hepatocytes and human liver microsomes, suggesting slow metabolism. Sulfisoxazole also shows antiviral activity against SARS-CoV-2, albeit with limited effectiveness according to various assays, including cytotoxicity and 3CL-Pro protease inhibition. Furthermore, it has been identified to inhibit the Bile Salt Export Pump (BSEP), though at high IC50 values (>135000.0 nM), indicating weak inhibition. Overall, Sulfisoxazole’s broad bioactivity profile, significant pharmacokinetic properties, and multi-target inhibition suggest its potential application in various therapeutic areas, albeit with caution due to its hepatotoxicity and moderate liver toxicity..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Sulfisoxazole (Sulfafurazole) is a short-acting sulfonamide antibacterial with activity against a wide range of gram-negative and gram-positive organisms.Sulfisoxazole inhibits breast cancer exosome release by targeting endothelin receptor A.
Targets&IC50	ETA:0.60 microM, ETB:22 microM
Synonyms	Sulfafurazole, NU-445

Chemical Properties

Molecular Weight	267.30
Formula	C₁₁H₁₃N₃O₃S
Cas No.	127-69-5
Smiles	CC1=NOC(NS(=O)(=O)C2=CC=C(N)C=C2)=C1C
Relative Density.	1.411g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (935.28 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (7.48 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.7411 mL	18.7056 mL	37.4111 mL	187.0557 mL
5 mM	0.7482 mL	3.7411 mL	7.4822 mL	37.4111 mL
10 mM	0.3741 mL	1.8706 mL	3.7411 mL	18.7056 mL
20 mM	0.1871 mL	0.9353 mL	1.8706 mL	9.3528 mL
50 mM	0.0748 mL	0.3741 mL	0.7482 mL	3.7411 mL
100 mM	0.0374 mL	0.1871 mL	0.3741 mL	1.8706 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc