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Anti-MRSA agent 26
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Catalog No. T207519
Anti-MRSA agent 26 (compound 21) is an antibiotic that serves as a potent MRSA inhibitor. It exhibits a MIC of <0.015 μg/mL for MSSA and a MIC range of 0.015-0.06 μg/mL for MSSA, MRSE, and VRE. In a murine model of Staphylococcus aureus skin infection, Anti-MRSA agent 26 effectively clears the infection. It is a 7-deazapurine pyridine with potential application for treating topical infections caused by multidrug-resistant Gram-positive bacteria.
Anti-MRSA agent 26
Anti-MRSA agent 26
😃Good
Catalog No. T207519
Anti-MRSA agent 26 (compound 21) is an antibiotic that serves as a potent MRSA inhibitor. It exhibits a MIC of <0.015 μg/mL for MSSA and a MIC range of 0.015-0.06 μg/mL for MSSA, MRSE, and VRE. In a murine model of Staphylococcus aureus skin infection, Anti-MRSA agent 26 effectively clears the infection. It is a 7-deazapurine pyridine with potential application for treating topical infections caused by multidrug-resistant Gram-positive bacteria.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 10 mg | Inquiry | Backorder | |
| 50 mg | Inquiry | Backorder |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Anti-MRSA agent 26 (compound 21) is an antibiotic that serves as a potent MRSA inhibitor. It exhibits a MIC of <0.015 μg/mL for MSSA and a MIC range of 0.015-0.06 μg/mL for MSSA, MRSE, and VRE. In a murine model of Staphylococcus aureus skin infection, Anti-MRSA agent 26 effectively clears the infection. It is a 7-deazapurine pyridine with potential application for treating topical infections caused by multidrug-resistant Gram-positive bacteria. |
| In vitro | Anti-MRSA agent 26 (Compound 21) demonstrates no toxicity at a concentration of 10 μM towards Caco-2, DU-145, and MDCKII MDR1 cells within a 3-hour exposure. Furthermore, Anti-MRSA agent 26 exhibits remarkable activity against various Gram-positive pathogens, with a MIC of <0.015 μg/mL for MRSE, 0.015-0.03 μg/mL for MRSA, VRE1, VRE5, and 0.06 μg/mL for MSSA, when administered in the range of 0.015-16 μg/mL over 20-24 hours. |
| In vivo | Compound 21, an anti-MRSA agent, is applied as a 2% cream on wounds twice daily, with a 6-hour interval between applications, over a period of 5 days. This treatment significantly reduces bacterial load in a mouse model of Staphylococcus aureus skin infection. |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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