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Anti-PBK/TOPK Antibody (2B766)
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Catalog No. TMAY-01109
Alias TOPK, SPK, PDZ binding kinase, Nori-3, HEL164, CT84
Anti-PBK/TOPK Antibody (2B766) is a Mouse antibody targeting PBK/TOPK. Anti-PBK/TOPK Antibody (2B766) can be used in ELISA(Cap).
Anti-PBK/TOPK Antibody (2B766)
Anti-PBK/TOPK Antibody (2B766)
😃Good
Catalog No. TMAY-01109Alias TOPK, SPK, PDZ binding kinase, Nori-3, HEL164, CT84
Anti-PBK/TOPK Antibody (2B766) is a Mouse antibody targeting PBK/TOPK. Anti-PBK/TOPK Antibody (2B766) can be used in ELISA(Cap).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 20 μL | $68 | 7-10 days | |
| 100 μL | $198 | 7-10 days |
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Antigen Details
Chemical Properties
| Description | Anti-PBK/TOPK Antibody (2B766) is a Mouse antibody targeting PBK/TOPK. Anti-PBK/TOPK Antibody (2B766) can be used in ELISA(Cap). |
| Alias | TOPK, SPK, PDZ binding kinase, Nori-3, HEL164, CT84 |
| Ig Type | Monoclonal Mouse IgG1 |
| Clone | 2B766 |
| Reactivity | Human |
| Application | ELISA(Cap) |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human PBK / TOPK (rh PBK / TOPK; TMPY-04547; NP_060962.2; Met1-Val322). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | PDZ binding kinase (PBK), also known as TOPK (T-LAK cell-originated protein kinase), is a serine/threonine kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family, and has all the characteristic protein kinase subdomains and a C-terminal PDZ-binding T/SXV motif. PBK is expressed in the testis restrictedly expressed in outer cell layer of seminiferous tubules, as well as placenta. PBK may be enrolled in the activation of lymphoid cells and support testicular functions, with a suggested role in the process of spermatogenesis. This mitotic kinase phosphorylates MAP kinase p38 and seems to be active in mitosis. When phosphorylated, PBK forms a protein-protein interaction with tumor suppressor p53 (TP53), leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage. The expression level of PBK is thus upregulated in a variety of neoplasms including hematological malignancies. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Human PBK / TOPK Protein (TMPY-04547) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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