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Roquinimex

Name: Roquinimex
Brand: TargetMol
SKU: T4412
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T4412Cas No. 84088-42-6

Alias LS2616, Linomide, FCF89, ABR212616

Roquinimex (FCF89) (Linomide) is a quinoline derivative immunostimulant which increases NK cell activity and macrophage cytotoxicity; inhibits angiogenesis and reduces the secretion of TNF alpha.

Roquinimex

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Purity: 97.69%

Catalog No. T4412Alias LS2616, Linomide, FCF89, ABR212616Cas No. 84088-42-6

Roquinimex (FCF89) (Linomide) is a quinoline derivative immunostimulant which increases NK cell activity and macrophage cytotoxicity; inhibits angiogenesis and reduces the secretion of TNF alpha.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$30	In Stock	In Stock
5 mg	$48	In Stock	In Stock
10 mg	$81	In Stock	In Stock
25 mg	$156	In Stock	In Stock
50 mg	$247	In Stock	In Stock
100 mg	$396	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$66	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:97.69%

Appearance:Solid

Color:White

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Product Introduction

Roquinimex AI Summary

Roquinimex demonstrates significant bioactivity across a range of biological assays. It has shown inhibitory effects on acute experimental autoimmune encephalomyelitis in SJL/N mice, with inhibition levels ranging from 35.0% to 71.0% at doses between 0.2 mg/kg/day and 5 mg/kg/day administered orally or subcutaneously. The compound also exhibits anti-inflammatory and immunomodulatory properties, evidenced by its ability to inhibit proteinuria and anti-DNA antibody production in murine models of chronic graft-versus-host disease and autoimmune diseases. In angiogenesis-related bioactivities, Roquinimex inhibits blood vessel formation in the CAM angiogenesis assay with an ED50 of 60.1 µg/embryo and demonstrates inhibitory effects on HUVEC proliferation with an IC50 of 13,950 nM. Additionally, it shows antiproliferative activity against PC-3 prostate cancer cells, albeit with a relatively high IC50 of >100,000 nM. The compound has also shown antiviral activity by inhibiting SARS-CoV-2 induced cytotoxicity in both Caco-2 and VERO-6 cells at a concentration of 10 μM, although with modest inhibition percentages. It moderately inhibits the SARS-CoV-2 3CL-Pro protease activity with a 17.31% inhibition at 20 μM. Pharmacokinetic data indicate that Roquinimex has a mean residence time (MRT) of 43.0 hours, a clearance (CL) of 0.082 mL/min/kg, and a half-life (T1/2) of 31.0 hours after intravenous administration in humans. It also shows high oral bioavailability and good absorption with a volume of distribution at steady state (Vdss) of 0.21 L/kg. Regarding its inhibitory activity on various transport pumps, Roquinimex shows weak inhibition of the human bile salt export pump (BSEP) and multidrug resistance-associated proteins (MRP2, MRP3, MRP4) with IC50 values exceeding 133,000 nM. Overall, Roquinimex possesses a broad spectrum of bioactivities including immunomodulatory, antiangiogenic, and antiviral properties, along with a pharmacokinetic profile indicative of potential therapeutic utility..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Roquinimex (FCF89) (Linomide) is a quinoline derivative immunostimulant which increases NK cell activity and macrophage cytotoxicity; inhibits angiogenesis and reduces the secretion of TNF alpha.
Synonyms	LS2616, Linomide, FCF89, ABR212616

Chemical Properties

Molecular Weight	308.33
Formula	C₁₈H₁₆N₂O₃
Cas No.	84088-42-6
Smiles	CN(C(=O)c1c(O)c2ccccc2n(C)c1=O)c1ccccc1
Relative Density.	1.357g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 83.3 mg/mL (270.17 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2433 mL	16.2164 mL	32.4328 mL	162.1639 mL
5 mM	0.6487 mL	3.2433 mL	6.4866 mL	32.4328 mL
10 mM	0.3243 mL	1.6216 mL	3.2433 mL	16.2164 mL
20 mM	0.1622 mL	0.8108 mL	1.6216 mL	8.1082 mL
50 mM	0.0649 mL	0.3243 mL	0.6487 mL	3.2433 mL
100 mM	0.0324 mL	0.1622 mL	0.3243 mL	1.6216 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc