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SP-420

Name: SP-420
Brand: TargetMol
SKU: T5344
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T5344Cas No. 911714-45-9

Alias SP 420

SP-420 is a novel orally active iron chelator.

SP-420

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Purity: 99.39%

Catalog No. T5344Alias SP 420Cas No. 911714-45-9

SP-420 is a novel orally active iron chelator.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$30	In Stock	In Stock
5 mg	$65	In Stock	In Stock
10 mg	$119	In Stock	In Stock
25 mg	$267	In Stock	In Stock
50 mg	$476	In Stock	In Stock
100 mg	$756	-	In Stock
1 mL x 10 mM (in DMSO)	$72	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.39%

Appearance:Solid

Color:White

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COA HPLC HNMR LCMS

Product Introduction

SP-420 AI Summary

SP-420 exhibits significant iron-clearing efficiency and diverse bioactivity. In bile-duct-cannulated Sprague-Dawley rats, it significantly reduces iron in bile, liver, and cardiac tissues across various dosages and durations, demonstrating a high 97.0% clearance of iron in bile at 300 µmol/kg. In non-iron-overloaded and iron-overloaded Cebus apella, it shows high iron excretion in feces at 75 µmol/kg (93.0%) and minimal excretion in urine. The compound has a moderate hydrophobic property with a LogD7.4 value of 0.89 and exhibits high stability in Sprague-Dawley rat plasma. Additionally, SP-420 has shown promising antiviral activity against SARS-CoV-2, inhibiting virus-induced cytotoxicity in VERO-6 and Caco-2 cells, with 2.67% inhibition at 10 µM after 48 hours. It also inhibits SARS-CoV-2 3CL-Pro protease by 18.24% at a concentration of 20 µM. Furthermore, it acts as a potential HDAC6 inhibitor, exhibiting inhibitory activities of -11.36% and -6.58% in different enzymatic assays. These findings highlight SP-420’s multifaceted potential in both iron-related conditions and antiviral treatments..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	SP-420 is a novel orally active iron chelator.
Synonyms	SP 420

Chemical Properties

Molecular Weight	355.41
Formula	C₁₆H₂₁NO₆S
Cas No.	911714-45-9
Smiles	OC1=C(C=CC(OCCOCCOC)=C1)C2=N[C@](C(O)=O)(C)CS2
Relative Density.	1.32 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 35 mg/mL (98.48 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8137 mL	14.0683 mL	28.1365 mL	140.6826 mL
5 mM	0.5627 mL	2.8137 mL	5.6273 mL	28.1365 mL
10 mM	0.2814 mL	1.4068 mL	2.8137 mL	14.0683 mL
20 mM	0.1407 mL	0.7034 mL	1.4068 mL	7.0341 mL
50 mM	0.0563 mL	0.2814 mL	0.5627 mL	2.8137 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc