Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Avibactam sodium (NXL-104) dihydrate inhibits CTX-M-15 and β-lactamase TEM-1 with IC 50 s of 5 nM and 8 nM, respectively. Avibactam sodium dihydrate is a reversible and covalent inhibitor of non-β-lactam β-lactamase [1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 10-14 weeks | $ 1,520.00 | |
50 mg | 10-14 weeks | $ 1,980.00 | |
100 mg | 10-14 weeks | $ 2,500.00 |
Description | Avibactam sodium (NXL-104) dihydrate inhibits CTX-M-15 and β-lactamase TEM-1 with IC 50 s of 5 nM and 8 nM, respectively. Avibactam sodium dihydrate is a reversible and covalent inhibitor of non-β-lactam β-lactamase [1]. |
In vitro | Avibactam, a molecule with minimal antibacterial activity, selectively inhibits class A and C β-lactamases, excluding metallo types and Acinetobacter OXA carbapenemases [2]. When combined with ceftazidime (0-256 mg/L), this compound effectively halts the growth of 16 bla KPC-2 positive and 1 bla OXA-232 positive Klebsiella pneumonia strains, exhibiting minimum inhibitory concentrations (MIC) of 50 and 90 for both at 8 mg/L [4]. |
In vivo | Ceftazidime-Avibactam, administered at a dosage of 0.375 mg/g subcutaneously every 8 hours for 10 days, exhibited significant therapeutic efficacy against K. pneumoniae strain Y8 infections in a mouse model, as evidenced by enhanced survival and reduced bacterial counts in the spleen and liver. Additionally, a single dose of Avibactam (64 mg/kg; s.c.) demonstrated a mean estimated half-life of 0.24 hours in the plasma of neutropenic mice with Pseudomonas aeruginosa lung infections. In a specific study, six-week-old female BALB/c mice infected with K. pneumoniae strain Y8 were treated with this combination. Results showed a 70% mortality rate in the infected group within four days, while all mice in the PBS control group died within 13 days. Conversely, mice treated with Ceftazidime-Avibactam survived the entire 10-day treatment period, with a 100% mortality rate observed within four days post-treatment cessation. This highlights the compound's ability to significantly reduce bacterial load, offering a potentially effective treatment option for these infections. |
Molecular Weight | 323.26 |
Formula | C7H14N3NaO8S |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Avibactam sodium dihydrate inhibitor inhibit