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Anti-Nicastrin Antibody (4B647)
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Catalog No. TMAY-01719
Alias nicastrin, Nct, NCSTN, mKIAA0253, Kiaa0253, D1Dau13e, Aph2, AA727311, 9430068N19Rik
Anti-Nicastrin Antibody (4B647) is a Rabbit antibody targeting Nicastrin. Anti-Nicastrin Antibody (4B647) can be used in FCM.
Anti-Nicastrin Antibody (4B647)
Anti-Nicastrin Antibody (4B647)
😃Good
Catalog No. TMAY-01719Alias nicastrin, Nct, NCSTN, mKIAA0253, Kiaa0253, D1Dau13e, Aph2, AA727311, 9430068N19Rik
Anti-Nicastrin Antibody (4B647) is a Rabbit antibody targeting Nicastrin. Anti-Nicastrin Antibody (4B647) can be used in FCM.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $269 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Rabbit Monoclonal Application: FCM Reactivity: Human |
| Alias | nicastrin, Nct, NCSTN, mKIAA0253, Kiaa0253, D1Dau13e, Aph2, AA727311, 9430068N19Rik |
| Ig Type | Rabbit IgG |
| Clone | 4B647 |
| Reactivity | Human |
| Verified Activity | Flow cytometric analysis of Human NCSTN expression on HepG2 cells. Cells were stained with purified anti-Human NCSTN, then a FITC-conjugated second step antibody. The histogram were derived from gated events with the forward and side light-scatter characteristics of intact cells. |
| Application | FCM |
| Recommended Dose | FCM: 1:25-1:100 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Human Nicastrin / NCSTN (rh Nicastrin / NCSTN; TMPY-01297; NP_056146.1; Met1-Glu669). |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Nicastrin (NCST, or NCT), a single-pass membrane glycoprotein that harbors a large extracellular domain, is an essential component of the gamma-secretase complex. Several lines of evidence indicate that the members of these complexes could also contribute to the control of cell death. NCT controls cell death via phosphoinositide 3-kinase/Akt and p53-dependent pathways and that this function remains independent of the activity and molecular integrity of the gamma-secretase complexes. Increasing pieces of evidence have shown that Nicastrin/NCSTN plays a crucial role in gamma-cleavage of the amyloid precursor protein (APP). The glycoprotein Nicastrin is an essential component of the gamma-secretase complex, a high molecular weight complex that also contains the presenilin proteins, Aph-1 and Pen-2. The gamma-secretase complex is not only involved in APP processing but also in the processing of an increasing number of another type I integral membrane proteins. As the largest subunit of the gamma-secretase complex, Nicastrin plays a crucial role in its activation. Inhibition of NCSTN demonstrated an altered gamma-cleavage activity, suggesting its potential implication in developing Alzheimer's disease (AD). Besides, Nicastrin can function to maintain epithelial to mesenchymal transition during breast cancer progression. Anti-nicastrin polyclonal and monoclonal antibodies were able to decrease notch1 and vimentin expression and reduced the invasive capacity of breast cancer cells in vitro. |
| Conjucates | Unconjugated |
| Others Formats | FITC/PE |
| Antibody Types Available | 3 |
| Immunogen | Recombinant Protein: Human Nicastrin / NCSTN protein (TMPY-01297) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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