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Anthraflavic acid

Name: Anthraflavic acid
Brand: TargetMol
SKU: T5941
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T5941Cas No. 84-60-6

Alias 2,6-Dihydroxyanthraquinone

Anthraflavic acid (2,6-Dihydroxyanthraquinone), a flavonoid, is a potent IQ mutagenicity and cytochrome P-448 inhibitor.

Anthraflavic acid

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Purity: 98.37%

Catalog No. T5941Alias 2,6-DihydroxyanthraquinoneCas No. 84-60-6

Anthraflavic acid (2,6-Dihydroxyanthraquinone), a flavonoid, is a potent IQ mutagenicity and cytochrome P-448 inhibitor.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
100 mg	$29	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$44	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:98.37%

Appearance:Solid

Color:Red

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	Anthraflavic acid (2,6-Dihydroxyanthraquinone), a flavonoid, is a potent IQ mutagenicity and cytochrome P-448 inhibitor.
In vitro	Anthraflavic acid is a potent inhibitor of IQ mutagenicity by virtue of its ability to inhibit both its microsomal and cytosolic activation pathways.
Kinase Assay	The metabolic activation of IQ to mutagens was determined using the Ames mutagenicity test ?and employing Salmonella lyphimurium strain TA98 ?and 10% hepatic preparations as activation systems.?IQ and anthraflavic acid were dissolved in DMSO so that the solvent levels never exceeded 100 μl?per phile.?In experiments where microsomes onl~ were used as the activation system, $9 mix was supplemented with 1 unit/plate of glucose-6-phosphate dehydrogenase.?Pre-incubation conditions are described in the appropriate legends.
Synonyms	2,6-Dihydroxyanthraquinone

Chemical Properties

Molecular Weight	240.21
Formula	C₁₄H₈O₄
Cas No.	84-60-6
Smiles	OC1=CC2=C(C=C1)C(=O)C1=CC(O)=CC=C1C2=O
Relative Density.	1.3032 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 5.5 mg/mL (22.9 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.1630 mL	20.8151 mL	41.6302 mL	208.1512 mL
5 mM	0.8326 mL	4.1630 mL	8.3260 mL	41.6302 mL
10 mM	0.4163 mL	2.0815 mL	4.1630 mL	20.8151 mL
20 mM	0.2082 mL	1.0408 mL	2.0815 mL	10.4076 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc