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Anti-DC-SIGN Antibody (7H439)
😃Good
Catalog No. TMAY-00446
Alias DC-SIGN, CD209 molecule, CD209
Anti-DC-SIGN Antibody (7H439) is a Rabbit antibody targeting DC-SIGN. Anti-DC-SIGN Antibody (7H439) can be used in FCM.
Anti-DC-SIGN Antibody (7H439)
Anti-DC-SIGN Antibody (7H439)
😃Good
Catalog No. TMAY-00446Alias DC-SIGN, CD209 molecule, CD209
Anti-DC-SIGN Antibody (7H439) is a Rabbit antibody targeting DC-SIGN. Anti-DC-SIGN Antibody (7H439) can be used in FCM.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $268 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Rabbit Monoclonal Application: FCM Reactivity: Human |
| Alias | DC-SIGN, CD209 molecule, CD209 |
| Ig Type | Rabbit IgG |
| Clone | 7H439 |
| Reactivity | Human |
| Verified Activity | Flow cytometric analysis of Human CD209 expression on DC. Cells were stained with purified anti-Human CD209, then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells. |
| Application | FCM |
| Recommended Dose | FCM: 1:25-1:100 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Human CD209/DC-SIGN (rh CD209/DC-SIGN; TMPY-00772; NP_066978.1; Lys62-Ala404). |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Dendritic cell (DC)-specific intercellular adhesion molecule 3 (ICAM-3) grabbing nonintegrin (DC-SIGN), also known as CD209, is a type II transmembrane protein on DCs with a C-type lectin extracellular domain, is capable of binding ICAM-3 on resting T cells in the secondary lymphoid organs, providing the initial contact between these cells during the establishment of cell-mediated immunity. It is not only a pattern recognition receptor but implicated in immunoregulation of DCs. It has an important role in mediating DC adhesion, migration, inflammation, activating primary T cell, triggering immune response and participating in immune escape of pathogens and tumors. DC-SIGN also mediates the capture and internalization of viral, bacterial, and fungal pathogens by dendritic cells, such as HIV-1, Ebola virus, cytomegalovirus, Dengue virus, and hepatitis C virus. DC-SIGN is unique in that it regulates adhesion processes, such as DC trafficking and T-cell synapse formation, as well as antigen capture. Moreover, even though several C-type lectins have been shown to bind HIV-1, DC-SIGN does not only capture HIV-1 but also protects it in early endosomes allowing HIV-1 transport by DC to lymphoid tissues, where it enhances trans infection of T cells.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
| Conjucates | Unconjugated |
| Others Formats | APC/FITC/PE |
| Antibody Types Available | 4 |
| Immunogen | Recombinant Protein: Human CD209/DC-SIGN Protein (TMPY-00772) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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