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Anti-DC-SIGN Antibody (7H439) (Synonyms: DC-SIGN, CD209 molecule, CD209)

Name: Anti-DC-SIGN Antibody (7H439)
Brand: TargetMol
SKU: TMAY-00446
Rating: 4.5 (1 reviews)

Catalog No. TMAY-00446 Copy Product Info

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Anti-DC-SIGN Antibody (7H439) is a Rabbit antibody targeting DC-SIGN. Anti-DC-SIGN Antibody (7H439) can be used in FCM.

Anti-DC-SIGN Antibody (7H439)

Copy Product Info

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Catalog No. TMAY-00446

Synonyms DC-SIGN, CD209 molecule, CD209

Anti-DC-SIGN Antibody (7H439) is a Rabbit antibody targeting DC-SIGN. Anti-DC-SIGN Antibody (7H439) can be used in FCM.

Anti-DC-SIGN Antibody
(7H439)

Pack Size	Price	USA Stock	Global Stock	Quantity
100 μL	$268	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Product Introduction

Bioactivity

Description	Anti-DC-SIGN Antibody (7H439) is a Rabbit antibody targeting DC-SIGN. Anti-DC-SIGN Antibody (7H439) can be used in FCM.
Synonyms	DC-SIGN, CD209 molecule, CD209
Ig Type	Rabbit IgG
Clone	7H439
Reactivity	Human
Specificity	Human DC-SIGN/CD209
Verified Activity	Flow cytometric analysis of Human CD209 expression on DC. Cells were stained with purified anti-Human CD209, then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells.
Application	FCM
Recommended Dose	FCM: 1:25-1:100
Antibody Type	Monoclonal
Host Species	Rabbit
Construction	This antibody was obtained from a rabbit immunized with purified, recombinant Human CD209/DC-SIGN (rh CD209/DC-SIGN; TMPY-00772; NP_066978.1; Lys62-Ala404).
Purification	Protein A
Appearance	Liquid
Formulation	0.2 μm filtered solution in PBS
Research Background	Dendritic cell (DC)-specific intercellular adhesion molecule 3 (ICAM-3) grabbing nonintegrin (DC-SIGN), also known as CD209, is a type II transmembrane protein on DCs with a C-type lectin extracellular domain, is capable of binding ICAM-3 on resting T cells in the secondary lymphoid organs, providing the initial contact between these cells during the establishment of cell-mediated immunity. It is not only a pattern recognition receptor but implicated in immunoregulation of DCs. It has an important role in mediating DC adhesion, migration, inflammation, activating primary T cell, triggering immune response and participating in immune escape of pathogens and tumors. DC-SIGN also mediates the capture and internalization of viral, bacterial, and fungal pathogens by dendritic cells, such as HIV-1, Ebola virus, cytomegalovirus, Dengue virus, and hepatitis C virus. DC-SIGN is unique in that it regulates adhesion processes, such as DC trafficking and T-cell synapse formation, as well as antigen capture. Moreover, even though several C-type lectins have been shown to bind HIV-1, DC-SIGN does not only capture HIV-1 but also protects it in early endosomes allowing HIV-1 transport by DC to lymphoid tissues, where it enhances trans infection of T cells.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy

Related Conjugates and Formulations

Conjucates	Unconjugated
Others Formats	APC/FITC/PE
Antibody Types Available	4

Antigen Details

Immunogen	Recombinant Protein: Human CD209/DC-SIGN Protein (TMPY-00772)
Antigen Species	Human

Chemical Properties

Stability & Storage

Stability & Storage	Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
Transport	Shipping with blue ice.

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Keywords

CD-209CD 209

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