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Lucanthone

Name: Lucanthone
Brand: TargetMol
SKU: T4569
Price: 51 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T4569Cas No. 479-50-5

Alias Lucantona, Lucanthonum

Lucanthone (Lucanthonum) is an inhibitor of Apurinic endonuclease-1 (APE-1).

Lucanthone

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Purity: 99.92%

Catalog No. T4569Alias Lucantona, LucanthonumCas No. 479-50-5

Lucanthone (Lucanthonum) is an inhibitor of Apurinic endonuclease-1 (APE-1).

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$51	In Stock	In Stock
2 mg	$73	In Stock	In Stock
5 mg	$128	In Stock	In Stock
10 mg	$198	In Stock	In Stock
25 mg	$422	In Stock	In Stock
50 mg	$623	In Stock	In Stock
100 mg	$882	-	In Stock
1 mL x 10 mM (in DMSO)	$143	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.92%

Appearance:Solid

Color:orange

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Lucanthone (Lucanthonum) is an inhibitor of Apurinic endonuclease-1 (APE-1).
In vitro	Lucanthone, an innovative autophagy inhibitor, induces apoptosis through cathepsin D activation and has been evaluated for its anticancer efficacy via MTT assay. Demonstrating a consistent reduction in viability across seven breast cancer cell lines, Lucanthone surpasses Chloroquine (CQ) in potency, evidenced by a significantly lower mean IC50 of 7.2 μM compared to 66 μM for CQ. Further validation through ATPlite assay and trypan blue exclusion in two representative cell lines (MDA-MB-231 and BT-20) confirms these findings.
Cell Research	Cell viability is assessed by MTT assay. Cells are seeded into 96-well microculture plates at 10,000 cells per well and allowed to attach for 24 h. Cells are then treated with Lucanthone (0, 0.5, 1, 5, 10, 20 and 40 μM), Chloroquine, Vorinostat, or combinations for 72 h. Following drug treatment, MTT is added and cell viability is quantified using a BioTek microplate reader. Effects on cell viability are also determined by measuring ATP levels using the ATPlite assay system and by trypan blue exclusion. Pro-apoptotic effects following in vitro drug exposure are quantified by propidium iodide (PI) staining and fluorescence-activated cell sorting (FACS) analysis of sub-G0/G1 DNA content[2]
Synonyms	Lucantona, Lucanthonum

Chemical Properties

Molecular Weight	340.48
Formula	C₂₀H₂₄N₂OS
Cas No.	479-50-5
Smiles	CCN(CC)CCNc1ccc(C)c2sc3ccccc3c(=O)c12
Relative Density.	1.184g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (176.22 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9370 mL	14.6852 mL	29.3703 mL	146.8515 mL
5 mM	0.5874 mL	2.9370 mL	5.8741 mL	29.3703 mL
10 mM	0.2937 mL	1.4685 mL	2.9370 mL	14.6852 mL
20 mM	0.1469 mL	0.7343 mL	1.4685 mL	7.3426 mL
50 mM	0.0587 mL	0.2937 mL	0.5874 mL	2.9370 mL
100 mM	0.0294 mL	0.1469 mL	0.2937 mL	1.4685 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc