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Azelaic acid

Azelaic acid
Azelaic acid (Anchoic acid) is a component of hair and skin conditioners and is produced by the ozonolysis of oleic acid. Azelaic acid has bacteriostatic activity against Propionibacterium acnes and Staphylococcus epidermidis by inhibiting protoprotein synthesis in microbial cells. Azelaic acid also has the ability to inhibit pigmentation due to its free radical scavenging action.
Catalog No. T0926Cas No. 123-99-9
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Purity:99.89%
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Azelaic acid

Purity: 99.89%
Catalog No. T0926Alias Nonanedioic acid, Finacea, Azelex, Anchoic acidCas No. 123-99-9

Azelaic acid (Anchoic acid) is a component of hair and skin conditioners and is produced by the ozonolysis of oleic acid. Azelaic acid has bacteriostatic activity against Propionibacterium acnes and Staphylococcus epidermidis by inhibiting protoprotein synthesis in microbial cells. Azelaic acid also has the ability to inhibit pigmentation due to its free radical scavenging action.
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Pack SizePriceAvailabilityQuantity
1 g$29In Stock
1 mL x 10 mM (in DMSO)$29In Stock
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Product Introduction

Bioactivity
Description
Azelaic acid (Anchoic acid) is a component of hair and skin conditioners and is produced by the ozonolysis of oleic acid. Azelaic acid has bacteriostatic activity against Propionibacterium acnes and Staphylococcus epidermidis by inhibiting protoprotein synthesis in microbial cells. Azelaic acid also has the ability to inhibit pigmentation due to its free radical scavenging action.
In vitro
AZ(Azelaic acid) combined with taurine (Tau) show more inhibitory effects in melanocytes than the treatment of AZ alone. AZ combined with Tau inhibits the melanin production and tyrosinase activity of B16F10 melanoma cells without significant cytotoxicity. Also inhibitory effects after treatment with these combined chemical are stronger than AZ alone on melanogenesis[2].
In vivo
Azelaic acid exhibits an anti-atherogenic effect. Its athero-protective effect is not related to changes in plasma lipid content. Azelaic acid supplementation decreases the level of CD68 macrophage marker by 34% (p<0.05)[1].
Cell Research
B16F10 melanoma cells are seeded at a density of 2.5×105 cells/60 mm culture dish. The cells are treated with Azelaic acid combined with Tau for 24 hr. The cells pellets are dissolved in 1 N NaOH at 60°C for 1 hr. The relative melanin content is determined by measuring the absorbance at 475 nm in ELISA reader. (Only for Reference)
AliasNonanedioic acid, Finacea, Azelex, Anchoic acid
Chemical Properties
Molecular Weight188.22
FormulaC9H16O4
Cas No.123-99-9
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
Ethanol: 35 mg/mL (186 mM)
DMSO: 55 mg/mL (292.21 mM)
H2O: 34 mg/mL (180.6 mM)
Solution Preparation Table
H2O/Ethanol/DMSO
1mg5mg10mg50mg
1 mM5.3129 mL26.5647 mL53.1293 mL265.6466 mL
5 mM1.0626 mL5.3129 mL10.6259 mL53.1293 mL
10 mM0.5313 mL2.6565 mL5.3129 mL26.5647 mL
20 mM0.2656 mL1.3282 mL2.6565 mL13.2823 mL
50 mM0.1063 mL0.5313 mL1.0626 mL5.3129 mL
100 mM0.0531 mL0.2656 mL0.5313 mL2.6565 mL

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