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Azelaic acid

Name: Azelaic acid
Brand: TargetMol
SKU: T0926
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0926Cas No. 123-99-9

Alias Nonanedioic acid, Finacea, Azelex, Anchoic acid

Azelaic acid (Anchoic acid) is a component of hair and skin conditioners and is produced by the ozonolysis of oleic acid. Azelaic acid has bacteriostatic activity against Propionibacterium acnes and Staphylococcus epidermidis by inhibiting protoprotein synthesis in microbial cells. Azelaic acid also has the ability to inhibit pigmentation due to its free radical scavenging action.

Azelaic acid

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Purity: 98.14%

Catalog No. T0926Alias Nonanedioic acid, Finacea, Azelex, Anchoic acidCas No. 123-99-9

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 g	$29	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.14%

Appearance:Solid

Color:White

Resource Download

COA GC HNMR LCMS

Product Introduction

Bioactivity

Description	Azelaic acid (Anchoic acid) is a component of hair and skin conditioners and is produced by the ozonolysis of oleic acid. Azelaic acid has bacteriostatic activity against Propionibacterium acnes and Staphylococcus epidermidis by inhibiting protoprotein synthesis in microbial cells. Azelaic acid also has the ability to inhibit pigmentation due to its free radical scavenging action.
In vitro	AZ(Azelaic acid) combined with taurine (Tau) show more inhibitory effects in melanocytes than the treatment of AZ alone. AZ combined with Tau inhibits the melanin production and tyrosinase activity of B16F10 melanoma cells without significant cytotoxicity. Also inhibitory effects after treatment with these combined chemical are stronger than AZ alone on melanogenesis[2].
In vivo	Azelaic acid exhibits an anti-atherogenic effect. Its athero-protective effect is not related to changes in plasma lipid content. Azelaic acid supplementation decreases the level of CD68 macrophage marker by 34% (p<0.05)[1].
Cell Research	B16F10 melanoma cells are seeded at a density of 2.5×105 cells/60 mm culture dish. The cells are treated with Azelaic acid combined with Tau for 24 hr. The cells pellets are dissolved in 1 N NaOH at 60°C for 1 hr. The relative melanin content is determined by measuring the absorbance at 475 nm in ELISA reader. (Only for Reference)
Synonyms	Nonanedioic acid, Finacea, Azelex, Anchoic acid

Chemical Properties

Molecular Weight	188.22
Formula	C₉H₁₆O₄
Cas No.	123-99-9
Smiles	OC(=O)CCCCCCCC(O)=O
Relative Density.	1 225 kg/m3. Temperature:25 °C.

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 35 mg/mL (185.95 mM), Sonication is recommended.

DMSO: 245 mg/mL (1301.67 mM), Sonication is recommended.

H2O: 34 mg/mL (180.64 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (10.63 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	5.3129 mL	26.5647 mL	53.1293 mL	265.6466 mL
5 mM	1.0626 mL	5.3129 mL	10.6259 mL	53.1293 mL
10 mM	0.5313 mL	2.6565 mL	5.3129 mL	26.5647 mL
20 mM	0.2656 mL	1.3282 mL	2.6565 mL	13.2823 mL
50 mM	0.1063 mL	0.5313 mL	1.0626 mL	5.3129 mL
100 mM	0.0531 mL	0.2656 mL	0.5313 mL	2.6565 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc