Shopping Cart

Your shopping cart is currently empty

Soyasaponin Bb

Name: Soyasaponin Bb
Brand: TargetMol
SKU: T3S0335
Price: 41 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

😃Good

Catalog No. T3S0335Cas No. 51330-27-9

Alias Soyasaponin I

1. Soyasaponin Bb (Soyasaponin I) can suppress Eca-976 cell growth, reverse effects on over expression of c-met, VEGF, and induce cell apoptosis through inhibiting HDAC1-NF-kappaB and activating PETEN and caspase-3 signaling pathways.

Soyasaponin Bb

Copy Product Info

😃Good

Purity: 99.62%

Catalog No. T3S0335Alias Soyasaponin ICas No. 51330-27-9

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$41	In Stock	In Stock
5 mg	$96	In Stock	In Stock
10 mg	$147	In Stock	In Stock
25 mg	$248	In Stock	In Stock
50 mg	$369	In Stock	In Stock
100 mg	$547	In Stock	In Stock
200 mg	$778	Inquiry	Inquiry

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.62%

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Soyasaponin Bb AI Summary

Soyasaponin Bb exhibits a range of bioactivities with potential therapeutic implications. It has shown efficacy in inhibiting DMBA-induced/TPA-promoted carcinogenesis in mice by reducing the number of skin papillomas per mouse by 40.0% after 20 weeks in a two-stage carcinogenesis test. In LPS-stimulated mouse RAW264.7 cells, the compound inhibits inducible nitric oxide synthase (iNOS) mRNA expression and activity in a dose-dependent manner, reducing iNOS mRNA expression with fold changes of 11.1, 8.8, 6.8, and 5.6 at concentrations of 25, 50, 100, and 200 µg/ml, respectively, and decreasing iNOS activity proportionally. Additionally, Soyasaponin Bb acts as a PPARgamma agonist in human HepG2 cells, with luciferase reporter gene assays revealing fold changes of 1.22, 1.36, and 1.79 at concentrations of 12.5, 25, and 50 µg/ml, respectively, after 24 hours. The compound also shows inhibitory action on glycosyltransferase enzymes, inhibiting human alpha-2,6-ST6GAL1 by 68.0% at 100 µM, rat alpha-2,3-O-ST3GALI by 59.0% at 500 µM, and demonstrating strong inhibitory activity of 83.0% on the latter enzyme at 1 mM. Furthermore, Soyasaponin Bb displays hepatoprotective properties against D-GaIN/LPS-induced liver injury in rat hepatocytes, though its exhibited activity in this context was reported as 0.0%. These data suggest that Soyasaponin Bb could be of significant interest across multiple therapeutic areas, including carcinogenesis, inflammation modulation, metabolic disorders, and hepatoprotection..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	1. Soyasaponin Bb (Soyasaponin I) can suppress Eca-976 cell growth, reverse effects on over expression of c-met, VEGF, and induce cell apoptosis through inhibiting HDAC1-NF-kappaB and activating PETEN and caspase-3 signaling pathways.
Synonyms	Soyasaponin I

Chemical Properties

Molecular Weight	943.12
Formula	C₄₈H₇₈O₁₈
Cas No.	51330-27-9
Smiles	[H][C@@]1(O[C@@H]2[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@]2([H])O[C@@H]2[C@@H](O)[C@H](O)[C@H](O[C@@]2([H])O[C@H]2CC[C@@]3(C)[C@@]([H])(CC[C@]4(C)[C@]3([H])CC=C3[C@]5([H])CC(C)(C)C[C@@H](O)[C@]5(C)CC[C@@]43C)[C@@]2(C)CO)C(O)=O)O[C@@H](C)[C@H](O)[C@@H](O)[C@H]1O
Relative Density.	1.41g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (47.71 mM), Sonication is recommended.

Ethanol: 1 mg/mL (1.06 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 2 mg/mL (2.12 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.0603 mL	5.3016 mL	10.6031 mL	53.0155 mL

DMSO

	1mg	5mg	10mg	50mg
5 mM	0.2121 mL	1.0603 mL	2.1206 mL	10.6031 mL
10 mM	0.1060 mL	0.5302 mL	1.0603 mL	5.3016 mL
20 mM	0.0530 mL	0.2651 mL	0.5302 mL	2.6508 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc