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Bax inhibitor peptide V5 acetate (Bax inhibitor peptide V5 acetate(579492-81-2 free base)) is a Bax-mediated apoptosis inhibitor, used for cancer treatment.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $44 | In Stock | |
2 mg | $61 | In Stock | |
5 mg | $90 | In Stock | |
10 mg | $132 | In Stock | |
25 mg | $290 | In Stock | |
50 mg | $478 | In Stock | |
100 mg | $619 | In Stock | |
200 mg | $809 | In Stock | |
1 mL x 10 mM (in DMSO) | $143 | In Stock |
Description | Bax inhibitor peptide V5 acetate (Bax inhibitor peptide V5 acetate(579492-81-2 free base)) is a Bax-mediated apoptosis inhibitor, used for cancer treatment. |
In vitro | Bax inhibitor peptide V5 (BIP-V5; 0-50 μM) decreases cell death in STF-cMyc cells but not in SW620 or NCI-H23 cells.[1]. V5 treatment upregulates expression of anti-apoptotic proteins Bcl-2 and XIAP by more than 3- and 11-fold and downregulates expression of apoptosis-inducing proteins Bax, Bad, and nuclear factor-κB-p65 by 10, 30, and nearly 50%, respectively[2]. |
In vivo | Bax inhibitor peptide V5 (BIP-V5; 100 μM) significantly improves islet function following isolation and improves islet graft function following transplantation in mice model[2]. |
Alias | Bax inhibitor peptide V5 acetate(579492-81-2 free base) |
Molecular Weight | 646.85 |
Formula | C29H54N6O8S |
Smiles | O=C(N[C@H](C(N[C@H](C(N[C@@H](CCCCN)C(O)=O)=O)CC(C)C)=O)CCSC)[C@@H]1CCCN1C([C@H](C(C)C)N)=O.CC(O)=O |
Relative Density. | no data available |
Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | H2O: 100 mg/mL (170.42 mM), Sonication is recommended. DMSO: 100 mg/mL (154.6 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
In Vivo Formulation | Saline: 100 mg/mL (154.6 mM), Heating is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.![]() | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO/H2O
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