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Bax inhibitor peptide V5 acetate

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Catalog No. T10463L
Alias Bax inhibitor peptide V5 acetate(579492-81-2 free base)

Bax inhibitor peptide V5 acetate (Bax inhibitor peptide V5 acetate(579492-81-2 free base)) is a Bax-mediated apoptosis inhibitor, used for cancer treatment.

Bax inhibitor peptide V5 acetate

Bax inhibitor peptide V5 acetate

😃Good
Purity: 99.2%
Catalog No. T10463LAlias Bax inhibitor peptide V5 acetate(579492-81-2 free base)
Bax inhibitor peptide V5 acetate (Bax inhibitor peptide V5 acetate(579492-81-2 free base)) is a Bax-mediated apoptosis inhibitor, used for cancer treatment.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$44In StockIn Stock
2 mg$61In StockIn Stock
5 mg$90In StockIn Stock
10 mg$132In StockIn Stock
25 mg$290In StockIn Stock
50 mg$478In StockIn Stock
100 mg$619In StockIn Stock
200 mg$809-In Stock
1 mL x 10 mM (in DMSO)$143In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Batch Information

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Purity:99.2%
Appearance:Solid
Color:White
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Product Introduction

Bioactivity
Description
Bax inhibitor peptide V5 acetate (Bax inhibitor peptide V5 acetate(579492-81-2 free base)) is a Bax-mediated apoptosis inhibitor, used for cancer treatment.
In vitro
Bax inhibitor peptide V5 (BIP-V5; 0-50 μM) decreases cell death in STF-cMyc cells but not in SW620 or NCI-H23 cells.[1]. V5 treatment upregulates expression of anti-apoptotic proteins Bcl-2 and XIAP by more than 3- and 11-fold and downregulates expression of apoptosis-inducing proteins Bax, Bad, and nuclear factor-κB-p65 by 10, 30, and nearly 50%, respectively[2].
In vivo
Bax inhibitor peptide V5 (BIP-V5; 100 μM) significantly improves islet function following isolation and improves islet graft function following transplantation in mice model[2].
SynonymsBax inhibitor peptide V5 acetate(579492-81-2 free base)
Chemical Properties
Molecular Weight646.85
FormulaC29H54N6O8S
SmilesO=C(N[C@H](C(N[C@H](C(N[C@@H](CCCCN)C(O)=O)=O)CC(C)C)=O)CCSC)[C@@H]1CCCN1C([C@H](C(C)C)N)=O.CC(O)=O
Relative Density.no data available
SequenceH-Val-Pro-Met-Leu-Lys-OH
Sequence ShortVPMLK
Storage & Solubility Information
Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
H2O: 100 mg/mL (154.6 mM), Sonication is recommended.
DMSO: 100 mg/mL (154.6 mM), Sonication is recommended.
In Vivo Formulation
Saline: 100 mg/mL (154.6 mM), Heating is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
H2O/DMSO
1mg5mg10mg50mg
1 mM1.5460 mL7.7298 mL15.4595 mL77.2977 mL
5 mM0.3092 mL1.5460 mL3.0919 mL15.4595 mL
10 mM0.1546 mL0.7730 mL1.5460 mL7.7298 mL
20 mM0.0773 mL0.3865 mL0.7730 mL3.8649 mL
50 mM0.0309 mL0.1546 mL0.3092 mL1.5460 mL
100 mM0.0155 mL0.0773 mL0.1546 mL0.7730 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

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