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PHYTOSPHINGOSINE

Name: PHYTOSPHINGOSINE
Brand: TargetMol
SKU: T9503
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T9503Cas No. 554-62-1

Phytosphingosine is a phospholipid with anticancer properties. In cancer cells, Phytosphingosine induces cell apoptosis through activation of caspase 8 and translocation of Bax.

PHYTOSPHINGOSINE

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Purity: 99.81%

Catalog No. T9503Cas No. 554-62-1

Phytosphingosine is a phospholipid with anticancer properties. In cancer cells, Phytosphingosine induces cell apoptosis through activation of caspase 8 and translocation of Bax.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$40	In Stock	In Stock
50 mg	$52	In Stock	In Stock
100 mg	$73	In Stock	In Stock
500 mg	$176	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.81%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

PHYTOSPHINGOSINE AI Summary

PHYTOSPHINGOSINE exhibits a broad spectrum of bioactivity across various biological targets and pathogens. It inhibits the proliferation of wild type human Jurkat cells and mutant Jurkat cells (SBR1, SBR2, and SBR3) with IC50 values of 3750.0 nM, 6570.0 nM, 5290.0 nM, and 4120.0 nM, respectively, as measured by MTT assay. The resistance indices for these mutant cell lines are 1.8, 1.4, and 1.1. The compound also shows fungicidal activity against various Candida species with a minimum fungicidal concentration (MFC) of 1.0 µg/ml. It inhibits Rhodococcus sp. M777 Endoglycoceramidase 2 with a Ki value of 850000.0 nM and affects mutant variants of this enzyme. Additional bioactivities include inhibition of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase) with a potency of 31622.8 nM, the vitamin D receptor (VDR) with a potency of 79432.8 nM, and Polymerase Kappa with a potency of 29934.9 nM. It also demonstrates partial inhibition of electric eel AChE (24.41% at 2 mg/ml) and horse BChE (7.46% at the same concentration). Notably, PHYTOSPHINGOSINE shows antiviral activity against SARS-CoV-2, inhibiting virus-induced cytotoxicity in Caco-2 and VERO-6 cells, with varying inhibition rates and IC50 values exceeding 20000.0 nM. Additionally, the compound inhibits SARS-CoV-2 3CL-Pro protease activity, although with a negative percentage inhibition at 20 µM. PHYTOSPHINGOSINE also demonstrates minor inhibition of human HDAC6 enzyme, with inhibition percentages of 0.56% and 4.33% in different enzymatic assays..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Phytosphingosine is a phospholipid with anticancer properties. In cancer cells, Phytosphingosine induces cell apoptosis through activation of caspase 8 and translocation of Bax.

Chemical Properties

Molecular Weight	317.51
Formula	C₁₈H₃₉NO₃
Cas No.	554-62-1
Smiles	CCCCCCCCCCCCCC[C@@H](O)[C@@H](O)[C@@H](N)CO
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

keep away from direct sunlight,store at low temperature,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 7.5 mg/mL (23.62 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (12.6 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1495 mL	15.7475 mL	31.4951 mL	157.4754 mL
5 mM	0.6299 mL	3.1495 mL	6.2990 mL	31.4951 mL
10 mM	0.3150 mL	1.5748 mL	3.1495 mL	15.7475 mL
20 mM	0.1575 mL	0.7874 mL	1.5748 mL	7.8738 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc