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Anti-GCSAM Antibody (3D490)

😃Good
Catalog No. TMAB-06399

Anti-GCSAM Antibody (3D490) is a Rabbit antibody targeting GCSAM. Anti-GCSAM Antibody (3D490) can be used in IHC-P,IHC-Fr,ICC/IF,IF,FCM,WB.

Anti-GCSAM Antibody (3D490)

Anti-GCSAM Antibody (3D490)

😃Good
Catalog No. TMAB-06399
Anti-GCSAM Antibody (3D490) is a Rabbit antibody targeting GCSAM. Anti-GCSAM Antibody (3D490) can be used in IHC-P,IHC-Fr,ICC/IF,IF,FCM,WB.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
25 μL$1507-10 days7-10 days
50 μL$2617-10 days7-10 days
100 μL$4737-10 days7-10 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
Anti-GCSAM Antibody (3D490) is a Rabbit antibody targeting GCSAM. Anti-GCSAM Antibody (3D490) can be used in IHC-P,IHC-Fr,ICC/IF,IF,FCM,WB.
Ig Type
IgG
Clone
3D490
Reactivity
Human
Application
Recommended Dose
IHC-P: 1:100-500; IHC-Fr: 1:100-500; ICC/IF: 1:100-500; IF: 1:100-500; FCM: 1:50-100; WB: 1:500-2000
Antibody Type
Monoclonal
Host SpeciesRabbit
Subcellular LocalizationCytoplasm. Cell membrane. Note=It relocalizes from the cytoplasm to podosome-like structures upon cell treatment with IL6.
Tissue SpecificityExpressed in diffuse large B-cell lymphoma (DLBCL) and several germinal center (GC)-like lymphoma cell lines (at protein level). Highly expressed in normal GC lymphocytes and GC-derived malignancies. Expressed in thymus and spleen.
ConstructionRecombinant Antibody
PurificationProtein A purified
AppearanceLiquid
Formulation10mM phosphate buffered saline (pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
Research BackgroundInvolved in the negative regulation of lymphocyte motility. It mediates the migration-inhibitory effects of IL6. Serves as a positive regulator of the RhoA signaling pathway. Enhancement of RhoA activation results in inhibition of lymphocyte and lymphoma cell motility by activation of its downstream effector ROCK. Is a regulator of B-cell receptor signaling, that acts through SYK kinase activation.
Antigen Details
Immunogen
A synthesized peptide: human GCSAM
Antigen Species
Human
Gene Name
GCSAM
Gene ID
Protein Name
Germinal center-associated signaling and motility protein
Uniprot ID
Function
Involved in the negative regulation of lymphocyte motility. It mediates the migration-inhibitory effects of IL6. Serves as a positive regulator of the RhoA signaling pathway. Enhancement of RhoA activation results in inhibition of lymphocyte and lymphoma cell motility by activation of its downstream effector ROCK.
Chemical Properties
Molecular WeightTheoretical: 21 kDa. Actual: 21 kDa.
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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