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BQR-695

Name: BQR-695
Brand: TargetMol
SKU: T4220
Price: 38 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T4220Cas No. 1513879-21-4

Alias NVP-BQR695, BQR695

BQR-695 (NVP-BQR695) is a phosphatidylinositol 4-kinase (PI4K) inhibitor with IC50s of 80 and 3.5 nM for human PI4KIIIβ and Plasmodium variant of PI4KIIIβ, respectively.

BQR-695

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Purity: 99.69%

Catalog No. T4220Alias NVP-BQR695, BQR695Cas No. 1513879-21-4

BQR-695 (NVP-BQR695) is a phosphatidylinositol 4-kinase (PI4K) inhibitor with IC50s of 80 and 3.5 nM for human PI4KIIIβ and Plasmodium variant of PI4KIIIβ, respectively.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$38	In Stock	In Stock
10 mg	$53	In Stock	In Stock
25 mg	$118	In Stock	In Stock
50 mg	$173	In Stock	In Stock
100 mg	$273	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$42	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.69%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	BQR-695 (NVP-BQR695) is a phosphatidylinositol 4-kinase (PI4K) inhibitor with IC50s of 80 and 3.5 nM for human PI4KIIIβ and Plasmodium variant of PI4KIIIβ, respectively.
Targets&IC50	P. falciparum (PI4KIIIβ):3.5 nM, PI4KIIIβ (human):80 nM
In vitro	BQR695 demonstrates no toxicity towards mature red blood cells (RBCs), triggers a schizont-stage halt akin to the effects seen in imidazopyrazine-treated parasites, and shows cross-resistance with imidazopyrazine-resistant strains. Administering 0.5 μM of KAI407 or BQR695 leads to the redistribution of GFP-PHOsh2 to the parasite's plasma membrane, indicating a decrease in intracellular PI4P due to the inhibition of PfPI4K activity.
Synonyms	NVP-BQR695, BQR695

Chemical Properties

Molecular Weight	352.39
Formula	C₁₉H₂₀N₄O₃
Cas No.	1513879-21-4
Smiles	CNC(=O)CNc1cnc2ccc(cc2n1)-c1ccc(OC)c(OC)c1
Relative Density.	1.250 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (141.89 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 2.5 mg/mL (7.09 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8378 mL	14.1888 mL	28.3776 mL	141.8882 mL
5 mM	0.5676 mL	2.8378 mL	5.6755 mL	28.3776 mL
10 mM	0.2838 mL	1.4189 mL	2.8378 mL	14.1888 mL
20 mM	0.1419 mL	0.7094 mL	1.4189 mL	7.0944 mL
50 mM	0.0568 mL	0.2838 mL	0.5676 mL	2.8378 mL
100 mM	0.0284 mL	0.1419 mL	0.2838 mL	1.4189 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc