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Menadione

Name: Menadione
Brand: TargetMol
SKU: T0449
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0449Cas No. 58-27-5

Alias Vitamin K3

Menadione (Vitamin K3) is a synthetic naphthoquinone without the isoprenoid side chain and biological activity, but can be converted to active vitamin K2, menaquinone, after alkylation in vivo.

Menadione

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Purity: 99.41%

Catalog No. T0449Alias Vitamin K3Cas No. 58-27-5

Menadione (Vitamin K3) is a synthetic naphthoquinone without the isoprenoid side chain and biological activity, but can be converted to active vitamin K2, menaquinone, after alkylation in vivo.

Pack Size	Price	USA Warehouse	Global Warehouse
100 mg	$31	In Stock	In Stock
500 mg	$65	In Stock	In Stock
1 g	$98	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$50	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.41%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	Menadione (Vitamin K3) is a synthetic naphthoquinone without the isoprenoid side chain and biological activity, but can be converted to active vitamin K2, menaquinone, after alkylation in vivo.
In vivo	In AR4-2J cells, Menadione (1-20 mM) inhibits cell proliferation in a dose- and time-dependent manner. In the RALA255-10G rat liver cell line, Menadione activates extracellular signal-regulated kinase and c-Jun N-terminal kinase. Furthermore, Menadione suppresses multidrug-resistant leukemia cell lines (IC50=13.5 mM) and primary leukemia cell lines (IC50=18 mM). At 100 mM, Menadione induces DNA fragmentation, leading to rapid cell death. Additionally, in normal pancreatic acinar cells, Menadione inhibits mitochondrial Ca(2+) uptake.
Synonyms	Vitamin K3

Chemical Properties

Molecular Weight	172.18
Formula	C₁₁H₈O₂
Cas No.	58-27-5
Smiles	O=C1C=2C(C(=O)C=C1C)=CC=CC2
Relative Density.	1.225 g/cm3

Storage & Solubility Information

Storage

keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 32 mg/mL (185.85 mM), Sonication is recommended.

DMSO: 55 mg/mL (319.43 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (11.62 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	5.8079 mL	29.0394 mL	58.0788 mL	290.3938 mL
5 mM	1.1616 mL	5.8079 mL	11.6158 mL	58.0788 mL
10 mM	0.5808 mL	2.9039 mL	5.8079 mL	29.0394 mL
20 mM	0.2904 mL	1.4520 mL	2.9039 mL	14.5197 mL
50 mM	0.1162 mL	0.5808 mL	1.1616 mL	5.8079 mL
100 mM	0.0581 mL	0.2904 mL	0.5808 mL	2.9039 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc