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N-octanoyl-L-Homoserine lactone

Catalog No. T37744 CAS 147852-84-4

Synonyms: C8-HSL, N-octanoyl-L-Homoserine lactone, OHL

N-octanoyl-L-Homoserine lactone (C8-HSL) is a diffusible exogenous Yersinia pestis population-sensing molecule that modulates LcrV virulence factors, controls gene expression by participating in population sensing, and affects cellular metabolism.N-octanoyl-L-Homoserine lactone is used to study cystic fiber Infection.

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N-octanoyl-L-Homoserine lactone Chemical Structure

N-octanoyl-L-Homoserine lactone, CAS 147852-84-4

Pack Size	Availability	Price/USD
5 mg	In stock	$ 39.00
10 mg	In stock	$ 72.00
25 mg	In stock	$ 155.00
50 mg	In stock	$ 263.00
100 mg	In stock	$ 393.00
500 mg	In stock	$ 888.00
1 mL * 10 mM (in DMSO)	In stock	$ 43.00

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Purity: 99.64%

Biological Description

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Storage & Solubility Information

Description

In vitro

Nitric oxide radical (NO) release was significantly higher when C8-HSL MPs were combined with particulate vaccines for measles and Zika. C8-HSL MPs showed immunostimulatory potential when combined with the influenza vaccine. The results showed that C8-HSL MPs were as immunogenic as FDA-approved adjuvants such as alum, MF59, and CpG. This proof-of-concept study showed that C8-HSL MP displayed adjuvant potential when combined with several particulate vaccines, indicating that C8-HSL MPs can increase the immunogenicity of both bacterial and viral vaccines.[1]

Synonyms	C8-HSL, N-octanoyl-L-Homoserine lactone, OHL
Molecular Weight	227.3
Formula	C12H21NO3
CAS No.	147852-84-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 60 mg/mL (263.97 mM)

DMF: 20 mg/mL

References and Literature

1. Kuo, A., Blough, N.V., and Dunlap, P.V. Multiple N-acyl-L-homoserine lactone autoinducers of luminescence in the marine symbiotic bacterium Vibrio fischeri Journal of Bacteriology 176(24), 7558-7565 (1994). 2. Lithgow, J.K., Wilkinson, A., Hardman, A., et al. The regulatory locus cinRI in Rhizobium leguminosarum controls a network of quorum-sensing loci Molecular Microbiology 37(1), 81-97 (2000). 3. McClean, K.H., Winson, M.K., Fish, L., et al. Quorum-sensing and Chromobacterium violaceum: Exploitation of violacein production and inhibition for the detection of N-acylhomoserine lactones Microbiology 143, 3703-3711 (1997). 4. Riedel, K., Hentzer, M., Geisenberger, O., et al. N-acylhomoserine-lactone-mediated communication between Pseudomonas aeruginosa and Burkholderia cepacia in mixed biofilms Microbiology 147, 3249-3262 (2001). 5. Winson, M.K., Camara, M., Latifi, A., et al. Multiple N-acyl-L-homoserine lactone signal molecules regulate production of virulence determinants and secondary metabolites in Pseudomonas aeruginosa Proceedings of the National Academy of Sciences of the United States of America 92, 9427-9431 (1995).

Related compound libraries

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Keywords

N-octanoyl-L-Homoserine lactone 147852-84-4 Microbiology/Virology Antibacterial C8-HSL OHL inhibitor inhibit

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