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Anti-Nectin-3 Antibody (6X959)
😃Good
Catalog No. TMAY-01253
Alias PVRR3, PVRL3, PRR3, PPR3, poliovirus receptor-related 3, nectin-3, FLJ90624, DKFZp566B0846, CDw113, CD113
Anti-Nectin-3 Antibody (6X959) is a Mouse antibody targeting Nectin-3. Anti-Nectin-3 Antibody (6X959) can be used in IHC-P.
Anti-Nectin-3 Antibody (6X959)
Anti-Nectin-3 Antibody (6X959)
😃Good
Catalog No. TMAY-01253Alias PVRR3, PVRL3, PRR3, PPR3, poliovirus receptor-related 3, nectin-3, FLJ90624, DKFZp566B0846, CDw113, CD113
Anti-Nectin-3 Antibody (6X959) is a Mouse antibody targeting Nectin-3. Anti-Nectin-3 Antibody (6X959) can be used in IHC-P.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $198 | 7-10 days |
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| Description | Anti-Nectin-3 Antibody (6X959) is a Mouse antibody targeting Nectin-3. Anti-Nectin-3 Antibody (6X959) can be used in IHC-P. |
| Alias | PVRR3, PVRL3, PRR3, PPR3, poliovirus receptor-related 3, nectin-3, FLJ90624, DKFZp566B0846, CDw113, CD113 |
| Ig Type | Monoclonal Mouse IgG1 |
| Clone | 6X959 |
| Reactivity | Human, Cynomolgus |
| Verified Activity | 1. Immunochemical staining PVRL3 in human placenta with mouse monoclonal antibody (1:60, formalin-fixed paraffin embedded sections). 2. Immunochemical staining PVRL3 in human hepatoma with mouse monoclonal antibody (1:60, formalin-fixed paraffin embedded sections). 3. Immunochemical staining PVRL3 in cynomolgus testis with mouse monoclonal antibody (1:60, formalin-fixed paraffin embedded sections). |
| Application | IHC-P |
| Recommended Dose | IHC-P: 1:50-1:200 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CD113 / Nectin-3 (rh CD113 / Nectin-3; TMPY-01154; NP_056295.1; Met1-Asp400). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Poliovirus receptor-related 3 (PVRL3), also known as Nectin-3 and CD113, is a member of the nectin family. PVRL3/Nectin-3 is an 83 kDa, type I transmembrane glycoprotein. Its precursor is 549 amino acids (aa) in length and contains an extended signal sequence of 57 aa, an extracellular domain (ECD) of 347 aa, a transmembrane segment of 21 aa, and a cytoplasmic region of 124 aa. Nectin-3 has three splicing variants, nectin-3alpha (biggest), -3beta (middle), and -3gamma (smallest). It is predominantly expressed in testis and placenta as well as in various cell lines, including epithelial cell lines. PVRL3/Nectin-3 plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with PVRL2/Nectin-2 at Sertoli-spermatid junctions. PVRL3/Nectin-3 is thus involved in the formation of cell-cell junctions, including adherens junctions and synapses. It has been shown to induce endocytosis-mediated down-regulation of PVR from the cell surface, resulting in the reduction of cell movement and proliferation. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Human CD113 / Nectin-3 protein (TMPY-01154) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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