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Anti-Phospho-MSK2 (Thr568) Polyclonal Antibody

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Catalog No. TMAC-02659

Anti-Phospho-MSK2 (Thr568) Polyclonal Antibody is a Rabbit antibody targeting Phospho-MSK2 (Thr568). Anti-Phospho-MSK2 (Thr568) Polyclonal Antibody can be used in WB,IHC.

Anti-Phospho-MSK2 (Thr568) Polyclonal Antibody

Anti-Phospho-MSK2 (Thr568) Polyclonal Antibody

😃Good
Catalog No. TMAC-02659
Anti-Phospho-MSK2 (Thr568) Polyclonal Antibody is a Rabbit antibody targeting Phospho-MSK2 (Thr568). Anti-Phospho-MSK2 (Thr568) Polyclonal Antibody can be used in WB,IHC.
Pack SizePriceAvailabilityQuantity
50 μL$2187-10 days
100 μL$3177-10 days
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Product Introduction

Bioactivity
Description
Anti-Phospho-MSK2 (Thr568) Polyclonal Antibody is a Rabbit antibody targeting Phospho-MSK2 (Thr568). Anti-Phospho-MSK2 (Thr568) Polyclonal Antibody can be used in WB,IHC.
Ig Type
IgG
Reactivity
Human,Mouse
Application
Recommended Dose
WB: 1:500-3000; IHC: 1:50-100
Antibody Type
Polyclonal
Host SpeciesRabbit
ConstructionPolyclonal Antibody
PurificationAntibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
AppearanceLiquid
FormulationRabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Research BackgroundSerine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factor RELA, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA transcriptional activity in response to TNF. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines. Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors.
Related Conjugates and Formulations
Conjucates
Unconjugated
Others Formats
Phospho
Antigen Details
Immunogen
Peptide sequence around phosphorylation site of threonine 568 (M-Q-T(p)-P-C) derived from Human MSK2
Antigen Species
human
Uniprot ID
Chemical Properties
Molecular WeightActual: 95 kDa.
Stability & Storage
Stability & StorageStore at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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