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MT-DADMe-ImmA

Name: MT-DADMe-ImmA
Brand: TargetMol
SKU: TQ0008
Price: 64 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TQ0008Cas No. 653592-04-2

Alias MTDIA, Methylthio-DADMe-Immucillin A

MT-DADMe-ImmA (MTDIA) is an inhibitor of human 5'-methylthioadenosine phosphorylase (MTAP, Ki: 90 pM).

MT-DADMe-ImmA

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Purity: 99.56%

Catalog No. TQ0008Alias MTDIA, Methylthio-DADMe-Immucillin ACas No. 653592-04-2

MT-DADMe-ImmA (MTDIA) is an inhibitor of human 5'-methylthioadenosine phosphorylase (MTAP, Ki: 90 pM).

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$64	In Stock	In Stock
5 mg	$137	In Stock	In Stock
10 mg	$237	In Stock	In Stock
25 mg	$419	In Stock	In Stock
50 mg	$589	In Stock	In Stock
100 mg	$828	In Stock	In Stock
200 mg	$1,090	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$172	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.56%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	MT-DADMe-ImmA (MTDIA) is an inhibitor of human 5'-methylthioadenosine phosphorylase (MTAP, Ki: 90 pM).
Targets&IC50	MTAP:90 pM (Ki, cell free)
In vitro	Treatment of cultured cells with MTA and MT-DADMe-ImmA inhibit MTAP, increase cellular MTA concentrations, decrease polyamines, and induce apoptosis in FaDu and Cal27, two head and neck squamous cell carcinoma cell lines. MT-DADMe-ImmA alone does not induce apoptosis in any cell line [2].
In vivo	MTAP activity slowly returns, giving a biological half-life for the action of oral MT-DADMe-ImmA of 6.3 days. The time-dependent growth of FaDu tumors in immunodeficient mice is suppressed by oral or intraperitoneal treatment with MT-DADMe-ImmA [2].
Cell Research	Cell viability is evaluated using the Alamar Blue assay. Cells are seeded onto 96-well plates at a density of 10^4 cells/well and incubated with increasing concentrations of MT-DADMe-ImmA (100 pM to 100 μM) for 4 days at fixed MTA concentrations (0, 5, 10, and 20 μM) [2].
Animal Research	Tumors were established in mice for 5 days prior to oral or intraperitoneal treatments with MT-DADMe-ImmA. Mice are treated with an oral dose of 21 mg/kg or an intraperitoneal dose of 5 mg/kg/day MT-DADMe-ImmA [2].
Synonyms	MTDIA, Methylthio-DADMe-Immucillin A

Chemical Properties

Molecular Weight	293.39
Formula	C₁₃H₁₉N₅OS
Cas No.	653592-04-2
Smiles	CSC[C@H]1CN(Cc2c[nH]c3c(N)ncnc23)C[C@@H]1O
Relative Density.	1.412 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (170.42 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.82 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.4084 mL	17.0422 mL	34.0843 mL	170.4216 mL
5 mM	0.6817 mL	3.4084 mL	6.8169 mL	34.0843 mL
10 mM	0.3408 mL	1.7042 mL	3.4084 mL	17.0422 mL
20 mM	0.1704 mL	0.8521 mL	1.7042 mL	8.5211 mL
50 mM	0.0682 mL	0.3408 mL	0.6817 mL	3.4084 mL
100 mM	0.0341 mL	0.1704 mL	0.3408 mL	1.7042 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc