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Edoxudine

Name: Edoxudine
Brand: TargetMol
SKU: T4374
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T4374Cas No. 15176-29-1

Alias EUDR, Epoxudine, Aedurid

Edoxudine (Epoxudine), an antiviral drug, is an analogue of thymidine and shows effectiveness against the herpes simplex virus. Edoxudine is used as a 5-fluorouracil (FU) modulator. Edoxudine may be used to enhance the therapeutic index of 5-FU by reducing the catabolism, prolonging the plasma and intratumoral concentrations of 5-FU, and offering protection to normal organs by increasing the endogenous uridine levels. It can also enhance the antitumour action of 5-FU.

Edoxudine

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Purity: 99.94%

Catalog No. T4374Alias EUDR, Epoxudine, AeduridCas No. 15176-29-1

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$35	In Stock	In Stock
25 mg	$71	In Stock	In Stock
50 mg	$113	In Stock	In Stock
100 mg	$197	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.94%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Edoxudine AI Summary

Edoxudine exhibits potent antiviral activity against various strains of herpes simplex virus (HSV-1 and HSV-2) with increasing inhibition rates as the concentration increases, achieving up to 100% inhibition at specific concentrations. It reduces plaque formation significantly in human embryonic lung fibroblast (HELF) and vero cells, with ID50 values ranging between 10.0 µM and 40.0 µM and MIC50 values from 20.0 µg/mL to 140000.0 nM. Notably, it also demonstrates low cytotoxicity in HELF, human foreskin fibroblast cells, and African green monkey Vero cells, with CC50 values greater than 780000.0 nM and 200.0 µg/mL. Furthermore, compound 169382 possesses selective antiviral effects against a broader range of viruses, including vaccinia virus, varicella-zoster virus (VZV), and Epstein-Barr virus (EBV), exhibiting EC50 values from 600.0 nM to 66400.0 nM. Against Mycobacterium tuberculosis, it shows inhibitory activity on thymidine monophosphate kinase (TMPK) with a Ki value of 1140000.0 nM. The compound also demonstrates cytostatic activity against L1210/0 and Raji/0 cells with ID50 values of 1.6 and 2.9 µg/mL respectively. Edoxudine's antiviral properties extend to SARS-CoV-2, where it prevents virus-induced cytotoxicity in Caco-2 and VERO-6 cells, although its potency remains relatively low with observed IC50 values greater than 100000.0 nM. It has been tested as a 3CL-Pro protease inhibitor for SARS-CoV-2, showing partial inhibition at 20 µM. In addition, it inhibits DNA repair enzymes, sodium fluorescein uptake in OATP-transfected CHO cells, and displays moderate cytotoxicity against select human cell lines, supporting its potential therapeutic implications in viral infection control and enzyme inhibition..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Synonyms

EUDR, Epoxudine, Aedurid

Chemical Properties

Molecular Weight	256.26
Formula	C₁₁H₁₆N₂O₅
Cas No.	15176-29-1
Smiles	CCc1cn([C@H]2C[C@H](O)[C@@H](CO)O2)c(=O)[nH]c1=O
Relative Density.	1.389 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (175.6 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (7.8 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.9023 mL	19.5114 mL	39.0229 mL	195.1143 mL
5 mM	0.7805 mL	3.9023 mL	7.8046 mL	39.0229 mL
10 mM	0.3902 mL	1.9511 mL	3.9023 mL	19.5114 mL
20 mM	0.1951 mL	0.9756 mL	1.9511 mL	9.7557 mL
50 mM	0.0780 mL	0.3902 mL	0.7805 mL	3.9023 mL
100 mM	0.0390 mL	0.1951 mL	0.3902 mL	1.9511 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc