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Anti-CD46 Antibody (8C827)
😃Good
Catalog No. TMAY-02294
Alias TRA2.10, TLX, MIC10, MCP, CD46 molecule, complement regulatory protein, AHUS2
Anti-CD46 Antibody (8C827) is a Mouse antibody targeting CD46. Anti-CD46 Antibody (8C827) can be used in FCM,ICC/IF.
Anti-CD46 Antibody (8C827)
Anti-CD46 Antibody (8C827)
😃Good
Catalog No. TMAY-02294Alias TRA2.10, TLX, MIC10, MCP, CD46 molecule, complement regulatory protein, AHUS2
Anti-CD46 Antibody (8C827) is a Mouse antibody targeting CD46. Anti-CD46 Antibody (8C827) can be used in FCM,ICC/IF.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $198 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-CD46 Antibody (8C827) is a Mouse antibody targeting CD46. Anti-CD46 Antibody (8C827) can be used in FCM,ICC/IF. |
| Alias | TRA2.10, TLX, MIC10, MCP, CD46 molecule, complement regulatory protein, AHUS2 |
| Ig Type | Monoclonal Mouse IgG1 |
| Clone | 8C827 |
| Reactivity | Human |
| Verified Activity | 1. Profile of anti-CD46 reactivity on HeLa cells analyzed by flow cytometry. 2. Immunofluorescence staining of Human CD46 in Hela cells. Cells were fixed with 4% PFA, blocked with 10% serum, and incubated with Mouse anti-Human CD46 monoclonal antibody (1:60) at 37°C 1 hour. Then cells were stained with the Alexa Fluor® 594-conjugated Goat Anti-mouse IgG secondary antibody (red) and counterstained with DAPI (blue). Positive staining was localized to cell membrane. |
| Application | FCM,ICC/IF |
| Recommended Dose | ICC-IF: 1:20-1:100; FCM: 1:25-1:100 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CD46 (rh CD46; TMPY-02023; EAW93471.1; Met1-Asp328). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | CD46, also known as Membrane Cofactor Protein (MCP), is a complement regulatory protein. CD46 is a type 1 membrane protein that plays an important inhibitory role in the complement system. CD46 is expressed in white blood cells, platelets, epithelial cells, and fibroblasts. Human CD46 shares 5% amino acid sequence identity with mouse and rat CD46. The importance of CD46 to complement regulation is underscored by the observation that genetic loss of CD46 leads to development of atypical hemolytic-uremic syndrome (aHUS), a disease characterized by uncontrolled complement activation. CD46 is implicated in the development and/or progression of selected cancer types. |
| Conjucates | Unconjugated |
| Others Formats | APC/FITC/PE |
| Antibody Types Available | 4 |
| Immunogen | Recombinant Human CD46 protein (TMPY-02023) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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