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Anti-MRP2 Antibody (3I477)
Catalog No. TMAB-08996 Copy Product Info
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Anti-MRP2 Antibody (3I477) is a Rabbit antibody targeting MRP2. Anti-MRP2 Antibody (3I477) can be used in FCM, IHC-P, IHC-Fr, IF.
Anti-MRP2 Antibody (3I477)
Copy Product Info🥰Excellent
Catalog No. TMAB-08996
Anti-MRP2 Antibody (3I477) is a Rabbit antibody targeting MRP2. Anti-MRP2 Antibody (3I477) can be used in FCM, IHC-P, IHC-Fr, IF.
Anti-MRP2 Antibody
(3I477)
(3I477)
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 μL | $263 | 7-10 days | 7-10 days | |
| 100 μL | $470 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
Stability & Storage
| Description | Anti-MRP2 Antibody (3I477) is a Rabbit antibody targeting MRP2. Anti-MRP2 Antibody (3I477) can be used in FCM, IHC-P, IHC-Fr, IF. |
| Ig Type | IgG |
| Clone | 3I477 |
| Reactivity | Human |
| Verified Activity | 1. Paraformaldehyde-fixed, paraffin embedded Human Liver; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with MRP2 Monoclonal Antibody, Unconjugated (TMAB-08996) at 1: 200 overnight at 4°C, followed by conjugation to the SP Kit (Rabbit) and DAB staining. 2. The A549 (H) cells were incubated in 5% BSA to block non-specific protein-protein interactions (30 min at r. T.). Primary Antibody (green): Rabbit Anti-MRP2 antibody (TMAB-08996): 1 μg/10^6 cells; Secondary Antibody (white blue): Goat anti-Rabbit IgG-FITC: 1 μg/test. Isotype Control (orange): Rabbit IgG. Blank control (black): PBS. Acquisition of 20,000 events was performed. |
| Application | |
| Recommended Dose | FCM: 1μg/Test; IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Subcellular Localization | Membrane; Multi-pass membrane protein. |
| Tissue Specificity | Found on the apical membrane of polarized cells in liver, kidney and intestine. The highest expression is found in liver. |
| Construction | Recombinant Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | multidrug resistance-associated protein 2 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia. Belongs to the ABC transporter family. |
| Immunogen | A synthesized peptide: human ABCC2 |
| Antigen Species | Human |
| Gene Name | ABCC2 |
| Gene ID | |
| Protein Name | Canalicular multispecific organic anion transporter 1 |
| Uniprot ID | |
| Function | Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter. |
| Molecular Weight | Theoretical: 174 kDa. |
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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