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Dihydrosanguinarine

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Catalog No. T4S2012Cas No. 3606-45-9
Alias Dihydro Sanguinarine, 13,14-Dihydrosanguinarine

Dihydrosanguinarine, a natural compound isolated from the leaves of [Macleaya microcarpa], exhibits antifungal and anticancer activity.

Dihydrosanguinarine

Dihydrosanguinarine

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Purity: 99.77%
Catalog No. T4S2012Alias Dihydro Sanguinarine, 13,14-DihydrosanguinarineCas No. 3606-45-9
Dihydrosanguinarine, a natural compound isolated from the leaves of [Macleaya microcarpa], exhibits antifungal and anticancer activity.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$64In StockIn Stock
5 mg$189In StockIn Stock
10 mg$313In StockIn Stock
25 mg$528In StockIn Stock
50 mg$752In StockIn Stock
100 mg$987In StockIn Stock
1 mL x 10 mM (in DMSO)$198In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Purity:99.77%
Color:White
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Product Introduction

Bioactivity
Description
Dihydrosanguinarine, a natural compound isolated from the leaves of [Macleaya microcarpa], exhibits antifungal and anticancer activity.
In vitro
Dihydro Sanguinarine may cause both necrosis and apoptosis of HL-60 cells[1].
In vivo
Dihydrosanguinarine was?effective against I. multifiliis with median effective concentration (EC(50)) values of 5.18mg/l.?The acute toxicities (LC(50)) of dihydrosanguinarine and dihydrochelerythrine for richadsin was 13.3mg/l,?The overall results provided important information for the potential application of dihydrosanguinarine and dihydrochelerythrine in the therapy of serious infection caused by I. multifiliis[2].
SynonymsDihydro Sanguinarine, 13,14-Dihydrosanguinarine
Chemical Properties
Molecular Weight333.34
FormulaC20H15NO4
Cas No.3606-45-9
SmilesCN1Cc2c3OCOc3ccc2-c2ccc3cc4OCOc4cc3c12
Relative Density.1.426g/cm3
Storage & Solubility Information
Storagekeep away from moisture,keep away from direct sunlight | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 5.2 mg/mL (15.6 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.9999 mL14.9997 mL29.9994 mL149.9970 mL
5 mM0.6000 mL2.9999 mL5.9999 mL29.9994 mL
10 mM0.3000 mL1.5000 mL2.9999 mL14.9997 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
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2 Enter the in vivo formulation:
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