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Isobavachalcone

Name: Isobavachalcone
Brand: TargetMol
SKU: T3861
Price: 55 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3861Cas No. 20784-50-3

Alias Isobacachalcone, Corylifolinin

Isobavachalcone (Corylifolinin) is a chalcone constituent of Angelica keiskei, has potent anti-inflammatory activity, possible can ameliorate neuronal injury in brain diseases associated with inflammation.

Isobavachalcone

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Purity: 99.76%

Catalog No. T3861Alias Isobacachalcone, CorylifolininCas No. 20784-50-3

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$55	In Stock	In Stock
10 mg	$93	In Stock	In Stock
25 mg	$197	In Stock	In Stock
50 mg	$293	In Stock	In Stock
100 mg	$437	In Stock	-
500 mg	$982	Inquiry	Inquiry
1 mL x 10 mM (in DMSO)	$61	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.76%

Resource Download

COA HPLC HNMR

Product Introduction

Isobavachalcone AI Summary

Isobavachalcone exhibits a broad spectrum of bioactivities across different biological targets and organisms. It demonstrates antifungal activity against Candida albicans and Cryptococcus neoformans with IC50 values of 3.0 µg/mL and 7.0 µg/mL, respectively. The compound also shows antibacterial activity against multiple strains, including methicillin-resistant Staphylococcus aureus, Bacillus subtilis, and Escherichia coli, with varying minimum inhibitory concentration (MIC) values. Additionally, it exhibits antiprotozoal activity against Bodo caudatus with an LC50 value of 4.36 µg/mL after 48 hours. Isobavachalcone displays significant inhibition of collagen-induced, arachidonic acid-induced, and platelet-activating factor-induced platelet aggregation in rabbit platelets, with IC50 values indicating high effectiveness. It also inhibits nitric oxide production in mouse RAW264.7 cells with an IC50 value of 1600 nM and shows anti-inflammatory properties by inhibiting NF-kappaB transactivation and LPS-induced nitric oxide production. Moreover, Isobavachalcone demonstrates cytotoxicity in various human cancer cell lines, including Raji, K562, A549, MCF7, and THP1 cells, with IC50 values indicating potent antitumor activity. It activates the Nrf2 pathway in HepG2 cells, suggesting cytoprotective properties, and inhibits enzymes such as human PTP1B and porcine pancreatic lipase with significant IC50 values. The compound also exhibits antioxidant activity and has strong inhibitory effects on SARS-CoV papain-like protease and human DHODH. Its potential in inhibiting fungal, bacterial, and viral targets along with its anti-inflammatory, cytotoxic, and antiproliferative activities make Isobavachalcone a promising candidate for further pharmacological research and development..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Isobavachalcone (Corylifolinin) is a chalcone constituent of Angelica keiskei, has potent anti-inflammatory activity, possible can ameliorate neuronal injury in brain diseases associated with inflammation.
Targets&IC50	OVCAR-8 cells:7.92 μM (IC50)
Synonyms	Isobacachalcone, Corylifolinin

Chemical Properties

Molecular Weight	324.37
Formula	C₂₀H₂₀O₄
Cas No.	20784-50-3
Smiles	CC(C)=CCc1c(O)ccc(C(=O)\C=C\c2ccc(O)cc2)c1O
Relative Density.	1.243g/cm3

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 58.82 mg/mL (181.34 mM), Sonication is recommended.

Chloroform, Dichloromethane, Ethyl Acetate, Acetone: Soluble

In Vivo Formulation

10% DMSO+90% Saline: 2.5 mg/mL (7.71 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0829 mL	15.4145 mL	30.8290 mL	154.1450 mL
5 mM	0.6166 mL	3.0829 mL	6.1658 mL	30.8290 mL
10 mM	0.3083 mL	1.5414 mL	3.0829 mL	15.4145 mL
20 mM	0.1541 mL	0.7707 mL	1.5414 mL	7.7072 mL
50 mM	0.0617 mL	0.3083 mL	0.6166 mL	3.0829 mL
100 mM	0.0308 mL	0.1541 mL	0.3083 mL	1.5414 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc