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Venadaparib

Name: Venadaparib
Brand: TargetMol
SKU: T9430
Price: 41 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T9430Cas No. 1681017-83-3

Alias NOV140101, IDX-1197

Venadaparib (NOV140101) (IDX-1197) is a potent, selective and orally active PARP inhibitor with IC50s of 1.4 nM and 1.0 nM for PARP1 and PARP2, respectively. Venadaparib is insensitive to PARP-5. Venadaparib prevents the repair of DNA single-strand breaks (SSBs) and can be used in solid tumor research.

Venadaparib

🥰Excellent

Purity: 99.86%

Catalog No. T9430Alias NOV140101, IDX-1197Cas No. 1681017-83-3

Pack Size	Price	Availability
1 mg	$41	In Stock
2 mg	$57	In Stock
5 mg	$97	In Stock
10 mg	$147	In Stock
25 mg	$297	In Stock
50 mg	$488	In Stock
100 mg	$716	In Stock
1 mL x 10 mM (in DMSO)	$97	In Stock

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Batch Information

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Purity:99.86%

Resource Download

COA LCMS HNMR HPLC

Product Introduction

Bioactivity

Description	Venadaparib (NOV140101) (IDX-1197) is a potent, selective and orally active PARP inhibitor with IC50s of 1.4 nM and 1.0 nM for PARP1 and PARP2, respectively. Venadaparib is insensitive to PARP-5. Venadaparib prevents the repair of DNA single-strand breaks (SSBs) and can be used in solid tumor research.
Targets&IC50	PARP1:0.5 nM(EC50), PARP1/PARP2:1.4 nM/1.0 nM
In vitro	Venadaparib significantly inhibits PARP1-mediated PAR expression with an EC50?of 0.5 nM In DNA damage-induced Hela cells[1].
In vivo	Oral administration of Venadaparib significantly inhibits PAR(>90%) in tumor tissues until 24 hr post-dose in the germline BRCA1-mutated ovarian cancer PDX model. Venadaparib also dose-dependently inhibits potent tumor growth compared to the Olaparib treatment group[1].
Synonyms	NOV140101, IDX-1197

Chemical Properties

Molecular Weight	406.45
Formula	C₂₃H₂₃FN₄O₂
Cas No.	1681017-83-3
Smiles	Fc1ccc(Cc2n[nH]c(=O)c3ccccc23)cc1C(=O)N1CC(CNC2CC2)C1
Relative Density.	1.43 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90 mg/mL (221.43 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4603 mL	12.3016 mL	24.6033 mL	123.0164 mL
5 mM	0.4921 mL	2.4603 mL	4.9207 mL	24.6033 mL
10 mM	0.2460 mL	1.2302 mL	2.4603 mL	12.3016 mL
20 mM	0.1230 mL	0.6151 mL	1.2302 mL	6.1508 mL
50 mM	0.0492 mL	0.2460 mL	0.4921 mL	2.4603 mL
100 mM	0.0246 mL	0.1230 mL	0.2460 mL	1.2302 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc