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inS3-54A18

Name: inS3-54A18
Brand: TargetMol
SKU: T15582
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T15582Cas No. 328998-53-4

inS3-54A18 is an effective inhibitor of STAT3. inS3-54A18 has anticancer effects.

inS3-54A18

🥰Excellent

Purity: 99.68%

Catalog No. T15582Cas No. 328998-53-4

inS3-54A18 is an effective inhibitor of STAT3. inS3-54A18 has anticancer effects.

Pack Size	Price	Availability
2 mg	$35	In Stock
5 mg	$59	In Stock
10 mg	$94	In Stock
25 mg	$163	In Stock
50 mg	$238	In Stock
100 mg	$337	In Stock
200 mg	$475	In Stock
1 mL x 10 mM (in DMSO)	$65	In Stock

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Purity:99.68%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	inS3-54A18 is an effective inhibitor of STAT3. inS3-54A18 has anticancer effects.
In vitro	inS3-54A18 selectively impedes STAT3's interaction with its inherent target sequences and diminishes the expression of genes downstream of STAT3. It significantly reduces the wound healing capacity in A549 and MDA-MB-231 cells to 64% and 76% at a concentration of 5μM, and further decreases healing to 47% and 39%, respectively, at 10μM. Notably, inS3-54A18 does not interfere with either the basal or IL-6-stimulated activation of STAT3, but specifically inhibits the expression of a STAT3 target gene, survivin.
In vivo	inS3-54A18 (200 mg/kg, p.o.) inhibits tumor growth, metastasis, and STAT3 target gene expression in an A549 cell mouse xenograft model[1].

Chemical Properties

Molecular Weight	373.83
Formula	C₂₃H₁₆ClNO₂
Cas No.	328998-53-4
Smiles	Oc1ccc(cc1)N1C(=O)\C(=C/c2ccc(Cl)cc2)C=C1c1ccccc1
Relative Density.	1.363 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 150 mg/mL (401.25 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6750 mL	13.3751 mL	26.7501 mL	133.7506 mL
5 mM	0.5350 mL	2.6750 mL	5.3500 mL	26.7501 mL
10 mM	0.2675 mL	1.3375 mL	2.6750 mL	13.3751 mL
20 mM	0.1338 mL	0.6688 mL	1.3375 mL	6.6875 mL
50 mM	0.0535 mL	0.2675 mL	0.5350 mL	2.6750 mL
100 mM	0.0268 mL	0.1338 mL	0.2675 mL	1.3375 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc