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inS3-54A18

Name: inS3-54A18
Brand: TargetMol
SKU: T15582
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T15582Cas No. 328998-53-4

inS3-54A18 is an effective inhibitor of STAT3. inS3-54A18 has anticancer effects.

inS3-54A18

🥰Excellent

Purity: 99.68%

Catalog No. T15582Cas No. 328998-53-4

inS3-54A18 is an effective inhibitor of STAT3. inS3-54A18 has anticancer effects.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$35	In Stock	In Stock
5 mg	$59	In Stock	In Stock
10 mg	$94	In Stock	In Stock
25 mg	$163	In Stock	In Stock
50 mg	$238	In Stock	In Stock
100 mg	$337	In Stock	In Stock
200 mg	$475	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$65	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.68%

Appearance:Solid

Color:Orange

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	inS3-54A18 is an effective inhibitor of STAT3. inS3-54A18 has anticancer effects.
In vitro	inS3-54A18 selectively impedes STAT3's interaction with its inherent target sequences and diminishes the expression of genes downstream of STAT3. It significantly reduces the wound healing capacity in A549 and MDA-MB-231 cells to 64% and 76% at a concentration of 5μM, and further decreases healing to 47% and 39%, respectively, at 10μM. Notably, inS3-54A18 does not interfere with either the basal or IL-6-stimulated activation of STAT3, but specifically inhibits the expression of a STAT3 target gene, survivin.
In vivo	inS3-54A18 (200 mg/kg, p.o.) inhibits tumor growth, metastasis, and STAT3 target gene expression in an A549 cell mouse xenograft model[1].

Chemical Properties

Molecular Weight	373.83
Formula	C₂₃H₁₆ClNO₂
Cas No.	328998-53-4
Smiles	Oc1ccc(cc1)N1C(=O)\C(=C/c2ccc(Cl)cc2)C=C1c1ccccc1
Relative Density.	1.363 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 150 mg/mL (401.25 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6750 mL	13.3751 mL	26.7501 mL	133.7506 mL
5 mM	0.5350 mL	2.6750 mL	5.3500 mL	26.7501 mL
10 mM	0.2675 mL	1.3375 mL	2.6750 mL	13.3751 mL
20 mM	0.1338 mL	0.6688 mL	1.3375 mL	6.6875 mL
50 mM	0.0535 mL	0.2675 mL	0.5350 mL	2.6750 mL
100 mM	0.0268 mL	0.1338 mL	0.2675 mL	1.3375 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc