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Benorilate

Name: Benorilate
Brand: TargetMol
SKU: T3276
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3276Cas No. 5003-48-5

Alias Salipran, Benorylate, Benortan, Benoral

Benorilate (Salipran) is the esterification product of paracetamol and acetylsalicylic acid with anti-inflammatory, analgesic and antipyretic properties.

Benorilate

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Purity: 99.85%

Catalog No. T3276Alias Salipran, Benorylate, Benortan, BenoralCas No. 5003-48-5

Benorilate (Salipran) is the esterification product of paracetamol and acetylsalicylic acid with anti-inflammatory, analgesic and antipyretic properties.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 g	$29	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.85%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Benorilate AI Summary

Benorilate has a moderate logP value of 2.15, indicating some lipophilicity, and exhibits a relatively fast observed second order rate constant (K2 = 4870.0 min-1) and pseudo-first order rate constant (k_obs = 81.33 s-1), suggesting significant reactivity or pharmacokinetic properties. It has a short half-life in human plasma (T1/2 = 0.02333 hr) and low metabolic stability, with a moderate solubility of 20.0 μg/mL at 21 degrees Celsius. In bioactivity assays, Benorilate acts as an inhibitor: 1. ROR gamma transcriptional activity with a potency of 14125.4 nM. 2. Delayed death in malarial parasite plastid with a potency of 19011.5 nM. 3. USP1/UAF1 with a potency of 89125.1 nM. 4. S16 Schwann cell PMP22 intronic element firefly luciferase assay with a potency of 32196.8 nM. 5. Ebola Virus entry in various screens with AC50 ranging from 39.81 μM to 39810.7 nM. Although previously reported with a low octanol-water partition coefficient (logP = 0.056) indicating high water solubility, it has demonstrated moderate liver toxicity. This is evidenced by ALT or AST serum activity 6 times the normal upper limit or alkaline phosphatase serum activity of 1.7 times the normal upper limit, with acute toxicity showing serum enzyme activity levels exceeding these thresholds. Also, cytolytic liver toxicity has been noted, though chronic liver diseases and tumors have not been observed. Finally, Benorilate shows stability in the presence of Porcine liver esterase, with 14.1% residual activity after 30 minutes at pH 7.4, suggesting potential for maintaining stability in biological environments with esterase activity..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Benorilate (Salipran) is the esterification product of paracetamol and acetylsalicylic acid with anti-inflammatory, analgesic and antipyretic properties.
Synonyms	Salipran, Benorylate, Benortan, Benoral

Chemical Properties

Molecular Weight	313.3
Formula	C₁₇H₁₅NO₅
Cas No.	5003-48-5
Smiles	C(OC1=CC=C(NC(C)=O)C=C1)(=O)C2=C(OC(C)=O)C=CC=C2
Relative Density.	1.2016 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (159.59 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.38 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1918 mL	15.9591 mL	31.9183 mL	159.5914 mL
5 mM	0.6384 mL	3.1918 mL	6.3837 mL	31.9183 mL
10 mM	0.3192 mL	1.5959 mL	3.1918 mL	15.9591 mL
20 mM	0.1596 mL	0.7980 mL	1.5959 mL	7.9796 mL
50 mM	0.0638 mL	0.3192 mL	0.6384 mL	3.1918 mL
100 mM	0.0319 mL	0.1596 mL	0.3192 mL	1.5959 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc