Shopping Cart
  • Remove All
  • TargetMol
    Your shopping cart is currently empty

Anti-IkB alpha/NFKBIA Antibody-FITC (6U300)

😃Good
Catalog No. TMAY-02203F
Alias nuclear factor of κ light polypeptide gene enhancer in B-cells inhibitor, alpha, nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, α, nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha, NFKBI, MAD-3, IKBA, IkB α

Anti-IkB alpha/NFKBIA Antibody-FITC (6U300) is a FITC-conjugated Mouse antibody targeting IkB alpha/NFKBIA. Anti-IkB alpha/NFKBIA Antibody-FITC (6U300) can be used in FCM.

Anti-IkB alpha/NFKBIA Antibody-FITC (6U300)

Anti-IkB alpha/NFKBIA Antibody-FITC (6U300)

😃Good
Catalog No. TMAY-02203FAlias nuclear factor of κ light polypeptide gene enhancer in B-cells inhibitor, alpha, nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, α, nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha, NFKBI, MAD-3, IKBA, IkB α
Anti-IkB alpha/NFKBIA Antibody-FITC (6U300) is a FITC-conjugated Mouse antibody targeting IkB alpha/NFKBIA. Anti-IkB alpha/NFKBIA Antibody-FITC (6U300) can be used in FCM.
Pack SizePriceAvailabilityQuantity
25 T$81 7-10 days
100 T$174 7-10 days
Bulk & Custom
Add to Cart
Questions
View More
Contact us for more batch information
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Introduction

Bioactivity
Description
Anti-IkB alpha/NFKBIA Antibody-FITC (6U300) is a FITC-conjugated Mouse antibody targeting IkB alpha/NFKBIA. Anti-IkB alpha/NFKBIA Antibody-FITC (6U300) can be used in FCM.
Aliasnuclear factor of κ light polypeptide gene enhancer in B-cells inhibitor, alpha, nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, α, nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha, NFKBI, MAD-3, IKBA, IkB α
Ig Type
Monoclonal Mouse IgG2b
Clone
6U300
Reactivity
Human
Verified Activity
NFKBIA expression in HeLa and Jurkat cells. The cells were treated according to manufacturer’s manual (BD Pharmingen™ Cat. No. 554714), and then stained with FITC Mouse anti-NFKBIA. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells.
Application
FCM
Recommended Dose
10 μl/Test, 0.1 mg/ml
Antibody Type
Monoclonal
Host SpeciesMouse
ConstructionThis antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human IkB alpha / NFKBIA (rh IkB alpha / NFKBIA; TMPY-01710; NP_065390.1; Phe 2-Leu 317) and conjugated with FITC under optimum conditions, the unreacted FITC was removed.
PurificationProtein A
AppearanceLiquid
FormulationPBS solution containing 0.5% BSA and 0.03%ProClin300
Research BackgroundNuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (IkB alpha, NFKBIA, or IKBA), is a member of the NF-kappa-B inhibitor family that function to inhibit the NF-kB transcription factor. NFKBIA inhibits NF-kB by masking the nuclear localization signals (NLS) of NF-kB proteins and keeping them sequestered in an inactive state in the cytoplasm. Also, NFKBIA blocks the ability of NF-κB transcription factors to bind to DNA, which is required for NF-kB's proper functioning. Signal-induced degradation of I kappa B alpha exposes the nuclear localization signal of NF-kappa B, thus allowing it to translocate into the nucleus and activate transcription from responsive genes. An autoregulatory loop is established when NF-kappa B induces expression of the I kappa B alpha gene and newly synthesized I kappa B alpha accumulates in the nucleus where it negatively regulates NF-kappa B-dependent transcription. As part of this post-induction repression, the nuclear export signal on I kappa B alpha mediates the transport of NF-kappa B-I kappa B alpha complexes from the nucleus to the cytoplasm. Deletion of NFKBIA has an effect that is similar to the effect of EGFR amplification in the pathogenesis of glioblastoma and is associated with comparatively short survival. Polymorphisms in NFKBIA may be important in pre-disposition to and outcome after treatment, of multiple myeloma (MM). The NFKBIA gene product, IkappaBalpha, binds to NF-kappaB preventing its activation and is important in mediating resistance to apoptosis in B-cell lymphoproliferative diseases.
Related Conjugates and Formulations
Conjucates
FITC
Others Formats
Unconjugated/HRP
Antibody Types Available
3
Antigen Details
Immunogen
Recombinant Human IkB alpha / NFKBIA Protein (TMPY-01710)
Antigen Species
Human
Chemical Properties
Stability & Storage
Stability & StorageStore at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight.
TransportShipping with blue ice.

Sci Citations

Calculator

  • Molarity Calculator
  • Dilution Calculator
  • Reconstitution Calculator
  • Molecular Weight Calculator

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Related Tags: buy Anti-IkB alpha/NFKBIA Antibody-FITC (6U300) | purchase Anti-IkB alpha/NFKBIA Antibody-FITC (6U300) | Anti-IkB alpha/NFKBIA Antibody-FITC (6U300) cost | order Anti-IkB alpha/NFKBIA Antibody-FITC (6U300)