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Treosulfan

Name: Treosulfan
Brand: TargetMol
SKU: T17159
Price: 33 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T17159Cas No. 299-75-2

Alias Treosulphan, NSC 39069

Treosulfan (NSC 39069) is a bifunctional alkylating agent used in the treatment of advanced ovarian cancer.[2]

Treosulfan

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Purity: 99.75%

Catalog No. T17159Alias Treosulphan, NSC 39069Cas No. 299-75-2

Treosulfan (NSC 39069) is a bifunctional alkylating agent used in the treatment of advanced ovarian cancer.[2]

Pack Size	Price	Availability
5 mg	$33	In Stock
10 mg	$53	In Stock
25 mg	$107	In Stock
50 mg	$193	In Stock
100 mg	$343	In Stock
200 mg	$479	In Stock
1 mL x 10 mM (in DMSO)	$37	In Stock

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Batch Information

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Purity:99.75%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Treosulfan (NSC 39069) is a bifunctional alkylating agent used in the treatment of advanced ovarian cancer.[2]
In vitro	METHODS: ES cell lines A4573, CHP-100, JR (NCI-EWS 94), RD-ES, SK-N-MC, TC32, and TC71 were treated with Treosulfan (NSC 39069)(1, 10, 100, 1000 μM), and cell viability was measured by MTT assay. RESULTS The IC50 values of A4573, CHP-100, JR (NCI-EWS 94), RD-ES, SK-N-MC, TC32, and TC71 were (35, 70, 100, 250, 75, 5, 50, 10 μM). [1]
In vivo	METHODS: NOD/SCID mice were injected with ES sarcoma cell line TC71 or CHP-100 in the left gastrocnemius muscle. When tumors were palpable, mice were injected with Treosulfan (NSC 39069) (3,000 mg/kg, i.p), busulfan (60 mg/kg, i.p), or vehicle (PBS/20% DMSO, i.p). RESULTS Treosulfan significantly inhibited tumor growth in both cell lines, whereas busulfan only caused an initial inhibition of tumor growth in the cell line TC71 and caused tumor growth in mice injected with the cell line CHP-100 on day 13 Moderately suppressed. [1]
Synonyms	Treosulphan, NSC 39069

Chemical Properties

Molecular Weight	278.3
Formula	C₆H₁₄O₈S₂
Cas No.	299-75-2
Smiles	CS(=O)(=O)OC[C@H](O)[C@@H](O)COS(C)(=O)=O
Relative Density.	1.305 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (359.32 mM), Sonication is recommended.

H2O: 50 mg/mL (179.66 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (14.37 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.5932 mL	17.9662 mL	35.9324 mL	179.6622 mL
5 mM	0.7186 mL	3.5932 mL	7.1865 mL	35.9324 mL
10 mM	0.3593 mL	1.7966 mL	3.5932 mL	17.9662 mL
20 mM	0.1797 mL	0.8983 mL	1.7966 mL	8.9831 mL
50 mM	0.0719 mL	0.3593 mL	0.7186 mL	3.5932 mL
100 mM	0.0359 mL	0.1797 mL	0.3593 mL	1.7966 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc