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cyclo(L-Pro-L-Tyr)

🥰Excellent
Catalog No. TP2333Cas No. 4549-02-4

Maculosin is a secondary metabolite of fungi and bacteria.

cyclo(L-Pro-L-Tyr)

cyclo(L-Pro-L-Tyr)

🥰Excellent
Purity: 98.81%
Catalog No. TP2333Cas No. 4549-02-4
Maculosin is a secondary metabolite of fungi and bacteria.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$39In StockIn Stock
5 mg$97In StockIn Stock
10 mg$155In StockIn Stock
25 mg$262In StockIn Stock
50 mg$389In StockIn Stock
100 mg$573In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Batch Information

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Purity:98.81%
Appearance:Solid
Color:White
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COA HPLC HNMR

Product Introduction

Bioactivity
Description
Maculosin is a secondary metabolite of fungi and bacteria.
In vitro
Maculosin?acts as a host-specific phytotoxin, inducing formation of weeping necrotic lesions in leaves of spotted knapweed (C. maculosa) when used at a concentration of 10 μM.?Maculosin reduces the growth of the plant pathogenic bacteria X. axonopodis and R. solanacearum (MICs = 31.25 μg/ml) as well as the pathogenic oomycetes P. cactorum, P. capsici, P. cinnamomi, P. infestans, and P. ultimum when used at concentrations ranging from 10 to 100 mg/ml.?Maculosin also inhibits the growth of M. luteus, M. smegmatis, S. cerevisiae, C. albicans, C. neoformans, and A. niger when used in combination with pyrrolnitrin or banegasin.
Chemical Properties
Molecular Weight260.29
FormulaC14H16N2O3
Cas No.4549-02-4
SmilesOc1ccc(C[C@@H]2NC(=O)[C@@H]3CCCN3C2=O)cc1
Relative Density.1.36 g/cm3 (Predicted)
Sequencecyclo(pro-tyr)
Sequence ShortPY
Storage & Solubility Information
Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 125 mg/mL (480.23 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+90% Saline: 3.3 mg/mL (12.68 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.8419 mL19.2093 mL38.4187 mL192.0934 mL
5 mM0.7684 mL3.8419 mL7.6837 mL38.4187 mL
10 mM0.3842 mL1.9209 mL3.8419 mL19.2093 mL
20 mM0.1921 mL0.9605 mL1.9209 mL9.6047 mL
50 mM0.0768 mL0.3842 mL0.7684 mL3.8419 mL
100 mM0.0384 mL0.1921 mL0.3842 mL1.9209 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

spotted knapweednon-toxicityMaculosinliver cancerInhibitorinhibitCyclo(Tyr-Pro)cyclo(L-Pro-L-Tyr)cyclo(LProLTyr)cyclo(L Pro L Tyr)antioxidantanti-cancerAlternaria alternata967564
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