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cyclo(L-Pro-L-Tyr)

🥰Excellent
Catalog No. TP2333Cas No. 4549-02-4

Maculosin is a secondary metabolite of fungi and bacteria.

cyclo(L-Pro-L-Tyr)

cyclo(L-Pro-L-Tyr)

🥰Excellent
Purity: 98.81%
Catalog No. TP2333Cas No. 4549-02-4
Maculosin is a secondary metabolite of fungi and bacteria.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$39In StockIn Stock
5 mg$97In StockIn Stock
10 mg$155In StockIn Stock
25 mg$262In StockIn Stock
50 mg$389In StockIn Stock
100 mg$573In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:98.81%
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COA HPLC HNMR

Product Introduction

Bioactivity
Description
Maculosin is a secondary metabolite of fungi and bacteria.
In vitro
Maculosin?acts as a host-specific phytotoxin, inducing formation of weeping necrotic lesions in leaves of spotted knapweed (C. maculosa) when used at a concentration of 10 μM.?Maculosin reduces the growth of the plant pathogenic bacteria X. axonopodis and R. solanacearum (MICs = 31.25 μg/ml) as well as the pathogenic oomycetes P. cactorum, P. capsici, P. cinnamomi, P. infestans, and P. ultimum when used at concentrations ranging from 10 to 100 mg/ml.?Maculosin also inhibits the growth of M. luteus, M. smegmatis, S. cerevisiae, C. albicans, C. neoformans, and A. niger when used in combination with pyrrolnitrin or banegasin.
Chemical Properties
Molecular Weight260.29
FormulaC14H16N2O3
Cas No.4549-02-4
SmilesOc1ccc(C[C@@H]2NC(=O)[C@@H]3CCCN3C2=O)cc1
Relative Density.1.36 g/cm3 (Predicted)
Storage & Solubility Information
Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 125 mg/mL (480.23 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+90% Saline: 3.3 mg/mL (12.68 mM), Sonication is recommeded.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.8419 mL19.2093 mL38.4187 mL192.0934 mL
5 mM0.7684 mL3.8419 mL7.6837 mL38.4187 mL
10 mM0.3842 mL1.9209 mL3.8419 mL19.2093 mL
20 mM0.1921 mL0.9605 mL1.9209 mL9.6047 mL
50 mM0.0768 mL0.3842 mL0.7684 mL3.8419 mL
100 mM0.0384 mL0.1921 mL0.3842 mL1.9209 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

spotted knapweednon-toxicityMaculosinliver cancerInhibitorinhibitCyclo(Tyr-Pro)cyclo(L-Pro-L-Tyr)cyclo(LProLTyr)cyclo(L Pro L Tyr)antioxidantanti-cancerAlternaria alternata967564
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