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Quercetagetin

Name: Quercetagetin
Brand: TargetMol
SKU: T8114
Price: 90 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T8114Cas No. 90-18-6

Alias 6-Hydroxyquercetin

Quercetagetin (6-Hydroxyquercetin) (6-Hydroxyquercetin) is the major flavonoid isolated from Citrus unshiu. It is a moderately potent and selective, cell-permeable pim-1 kinase inhibitor (IC50: 0.34 μM).

Quercetagetin

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Purity: 99.91%

Catalog No. T8114Alias 6-HydroxyquercetinCas No. 90-18-6

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$90	In Stock	In Stock
5 mg	$213	In Stock	In Stock
10 mg	$318	In Stock	In Stock
25 mg	$536	In Stock	In Stock
50 mg	$772	In Stock	In Stock
100 mg	$1,050	-	In Stock
500 mg	$2,090	-	In Stock
1 mL x 10 mM (in DMSO)	$225	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.91%

Appearance:Solid

Color:Yellow

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	Quercetagetin (6-Hydroxyquercetin) (6-Hydroxyquercetin) is the major flavonoid isolated from Citrus unshiu. It is a moderately potent and selective, cell-permeable pim-1 kinase inhibitor (IC50: 0.34 μM).
Targets&IC50	Pim2:3.5 μM, RSK2:2.82 μM, Pim1:0.34 μM, PKA:21.2 μM
In vitro	Quercetagetin inhibits PIM2, PKA, and RSK2 (IC50s: 3.45, 21.2, and 2.82 μM). Quercetagetin (0.1, 1, 10, and 100 μM, 72 hours) inhibits growth of RWPE2 prostate cancer cells with average ED50 is 3.8 μM [2].
In vivo	Quercetagetin significantly inhibits UVB-induced skin cancer development. Topical application of 4 or 20 nmol of Quercetagetin to mouse skin reduces tumor incidence by 32.0% and 46.7%, respectively [3].
Cell Research	Cell Line: RWPE2 prostate cancer cells. Concentration: 0.1, 1, 10, and 100 μM. Incubation Time: 72 hours [2]
Animal Research	Animal Model: SKH-1 hairless mice model. Dosage: 4 or 20 nmol. Administration: Topical application; 28 weeks [3]
Synonyms	6-Hydroxyquercetin

Chemical Properties

Molecular Weight	318.24
Formula	C₁₅H₁₀O₈
Cas No.	90-18-6
Smiles	Oc1ccc(cc1O)-c1oc2cc(O)c(O)c(O)c2c(=O)c1O
Relative Density.	1.912 g/cm3

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (785.57 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (12.57 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1423 mL	15.7114 mL	31.4228 mL	157.1141 mL
5 mM	0.6285 mL	3.1423 mL	6.2846 mL	31.4228 mL
10 mM	0.3142 mL	1.5711 mL	3.1423 mL	15.7114 mL
20 mM	0.1571 mL	0.7856 mL	1.5711 mL	7.8557 mL
50 mM	0.0628 mL	0.3142 mL	0.6285 mL	3.1423 mL
100 mM	0.0314 mL	0.1571 mL	0.3142 mL	1.5711 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc