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Dienestrol

Name: Dienestrol
Brand: TargetMol
SKU: T0035
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0035Cas No. 84-17-3

Alias Restrol, Dienoestrol, Dehydrostilbestrol, Cycladiene

Dienestrol (Restrol) is a synthetic and nonsteroidal estrogen, which is an estrogen receptor agonist. Estrogens can increase a normal clear discharge from the vagina and make the vulva and urethra healthy.

Dienestrol

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Purity: 98%

Catalog No. T0035Alias Restrol, Dienoestrol, Dehydrostilbestrol, CycladieneCas No. 84-17-3

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$30	In Stock	In Stock
25 mg	$46	In Stock	In Stock
50 mg	$67	In Stock	In Stock
100 mg	$93	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$74	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98%

Color:White

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Product Introduction

Dienestrol AI Summary

Dienestrol demonstrates a broad spectrum of biological activities and chemical properties. It shows a relative binding affinity (RBA) of 20.0 to the mouse estrogen receptor compared to estradiol, indicating significant interaction with this receptor. Chemically, it has a log P value of 4.5, denoting high lipophilicity, and a log Pe value of -4.53 across a PAMPA membrane, reflecting poor permeability. Biologically, Dienestrol exhibits protective effects against fragile X syndrome phenotypes in Fmr1 null mutant Drosophila, enhancing embryo viability with activity levels of 33.0% and 71.3% in respective assays. It shows potential inhibitory effects on tau fibril formation, human lipoxygenases (15-hLO and 12-hLO), histone lysine methyltransferase G9a, and BAZ2B. The compound also induces DNA re-replication in various cell lines, inhibits Glutaminase, Vif-A3G interactions, and Human tyrosyl-DNA phosphodiesterase 1 (TDP1). Metabolically, Dienestrol shows activity in UGT2B15 metabolism (26.0 pm/min/mg) but not in UGT1A1 (0.0 pm/min/mg). It inhibits sodium fluorescein uptake in OATP1B3-transfected CHO cells by 61.94% and in OATP1B1-transfected CHO cells by 48.7% at 10 µM concentration. In antiviral assays, Dienestrol presents mixed results. It shows weak inhibition of SARS-CoV-2 induced cytotoxicity in Caco-2 and VERO-6 cells, with inhibition rates of 4.06% and -0.1% respectively at 10 µM. The compound has a low activity against SARS-CoV-2 (USA-WA1/2020 strain) in HRCE cells, with a hit score of 0.02745. For antifolate-resistant parasites, Dienestrol inhibits luciferase expression in HepG2 cells with an IC50 of 1.24 µM, and shows similar concentrations for CC50 and CC90 (both 1.24 µM), indicating moderate potency and cytotoxicity. Overall, Dienestrol exhibits a comprehensive yet generally weak interaction profile with various enzymes, receptors, and viral targets, including potential inhibition of the SARS-CoV-2 3CL-Pro protease..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Dienestrol (Restrol) is a synthetic and nonsteroidal estrogen, which is an estrogen receptor agonist. Estrogens can increase a normal clear discharge from the vagina and make the vulva and urethra healthy.
Animal Research	s
Synonyms	Restrol, Dienoestrol, Dehydrostilbestrol, Cycladiene

Chemical Properties

Molecular Weight	266.33
Formula	C₁₈H₁₈O₂
Cas No.	84-17-3
Smiles	C\C=C(\C(=C\C)\c1ccc(O)cc1)/c1ccc(O)cc1
Relative Density.	1.184 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (187.74 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.7547 mL	18.7737 mL	37.5474 mL	187.7370 mL
5 mM	0.7509 mL	3.7547 mL	7.5095 mL	37.5474 mL
10 mM	0.3755 mL	1.8774 mL	3.7547 mL	18.7737 mL
20 mM	0.1877 mL	0.9387 mL	1.8774 mL	9.3869 mL
50 mM	0.0751 mL	0.3755 mL	0.7509 mL	3.7547 mL
100 mM	0.0375 mL	0.1877 mL	0.3755 mL	1.8774 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc