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Nebularine

Name: Nebularine
Brand: TargetMol
SKU: TNU0052
Price: 40 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TNU0052Cas No. 550-33-4

Alias 9-(beta-D-Ribofuranosyl)-9H-purine

Nebularine (9-(beta-D-Ribofuranosyl)-9H-purine) is a purine nucleoside analog with a broad spectrum of antitumor activity, targeting inert lymphoid malignancies and inducing apoptosis.The anticancer mechanism of Nebularine is dependent on the inhibition of DNA synthesis.

Nebularine

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Purity: 99.57%

Catalog No. TNU0052Alias 9-(beta-D-Ribofuranosyl)-9H-purineCas No. 550-33-4

Pack Size	Price	Availability
10 mg	$40	In Stock
25 mg	$81	In Stock
50 mg	$129	In Stock
100 mg	$213	In Stock
200 mg	$318	In Stock

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Batch Information

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Purity:99.57%

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	Nebularine (9-(beta-D-Ribofuranosyl)-9H-purine) is a purine nucleoside analog with a broad spectrum of antitumor activity, targeting inert lymphoid malignancies and inducing apoptosis.The anticancer mechanism of Nebularine is dependent on the inhibition of DNA synthesis.
Synonyms	9-(beta-D-Ribofuranosyl)-9H-purine

Chemical Properties

Molecular Weight	252.23
Formula	C₁₀H₁₂N₄O₄
Cas No.	550-33-4
Smiles	OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2cncnc12
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (218.05 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.9646 mL	19.8232 mL	39.6464 mL	198.2318 mL
5 mM	0.7929 mL	3.9646 mL	7.9293 mL	39.6464 mL
10 mM	0.3965 mL	1.9823 mL	3.9646 mL	19.8232 mL
20 mM	0.1982 mL	0.9912 mL	1.9823 mL	9.9116 mL
50 mM	0.0793 mL	0.3965 mL	0.7929 mL	3.9646 mL
100 mM	0.0396 mL	0.1982 mL	0.3965 mL	1.9823 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc