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Anti-CDK4 Antibody (8K220) (Synonyms: PSK-J3, cyclin-dependent kinase 4, CMM3)
Catalog No. TMAH-00254 Copy Product Info
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Anti-CDK4 Antibody (8K220) is an antibody targeting CDK4. Anti-CDK4 Antibody (8K220) can be used in ELISA,WB.
Anti-CDK4 Antibody (8K220)
Copy Product Info🥰Excellent
Catalog No. TMAH-00254
Synonyms PSK-J3, cyclin-dependent kinase 4, CMM3
Anti-CDK4 Antibody (8K220) is an antibody targeting CDK4. Anti-CDK4 Antibody (8K220) can be used in ELISA,WB.
Anti-CDK4 Antibody
(8K220)
(8K220)
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 μL | $208 | 7-10 days | 7-10 days | |
| 100 μL | $348 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
Stability & Storage
| Description | Anti-CDK4 Antibody (8K220) is an antibody targeting CDK4. Anti-CDK4 Antibody (8K220) can be used in ELISA,WB. |
| Synonyms | PSK-J3, cyclin-dependent kinase 4, CMM3 |
| Ig Type | Rabbit IgG |
| Clone | 8K220 |
| Reactivity | Human |
| Verified Activity | Western Blot -Positive WB detected in: Jurkat whole cell lysate, Hela whole cell lysate, 293 whole cell lysate, MCF-7 whole cell lysate, HepG2 whole cell lysate, K562 whole cell lysate, A549 whole cell lysate -All lanes: CDK4 antibody at 1:1500 -Secondary: Goat polyclonal to rabbit IgG at 1/50000 dilution -Predicted band size: 34, 21 kDa -Observed band size: 34 kDa |
| Application | |
| Recommended Dose | WB:1:500-1:5000. |
| Antibody Type | Monoclonal |
| Subcellular Localization | Cytoplasm. Nucleus. Nucleus membrane. |
| Construction | Recombinant Antibody |
| Purification | Affinity-chromatography |
| Appearance | Liquid |
| Formulation | Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Research Background | Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. |
| Conjucates | Unconjugated |
| Immunogen | A synthetic peptide: Human CDK4 |
| Antigen Species | Human |
| Gene Name | CDK4 |
| Gene ID | |
| Uniprot ID | |
| Biology Area | Isotype/Loading Controls, Epigenetics and Nuclear Signaling, Cancer, Cell biology |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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