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DMNB

Name: DMNB
Brand: TargetMol
SKU: T8637
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T8637Cas No. 20357-25-9

Alias 6-Nitroveratraldehyde

DMNB (6-Nitroveratraldehyde) is DNA-dependent protein kinase (DNA-PK) inhibitor with IC50 of 15 μM, an enzyme involved in the non-homologous end-joining (NHEJ) pathway of double-stranded DNA break (DSB) repair in human cells.

DMNB

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Purity: 97.87%

Catalog No. T8637Alias 6-NitroveratraldehydeCas No. 20357-25-9

Pack Size	Price	Availability	Quantity
200 mg	$29	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock

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Batch Information

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Purity:97.87%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	DMNB (6-Nitroveratraldehyde) is DNA-dependent protein kinase (DNA-PK) inhibitor with IC50 of 15 μM, an enzyme involved in the non-homologous end-joining (NHEJ) pathway of double-stranded DNA break (DSB) repair in human cells.
Synonyms	6-Nitroveratraldehyde

Chemical Properties

Molecular Weight	211.17
Formula	C₉H₉NO₅
Cas No.	20357-25-9
Smiles	COC1=C(OC)C=C(C(C=O)=C1)[N+]([O-])=O
Relative Density.	1.4194 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 22.5 mg/mL (106.55 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.7355 mL	23.6776 mL	47.3552 mL	236.7761 mL
5 mM	0.9471 mL	4.7355 mL	9.4710 mL	47.3552 mL
10 mM	0.4736 mL	2.3678 mL	4.7355 mL	23.6776 mL
20 mM	0.2368 mL	1.1839 mL	2.3678 mL	11.8388 mL
50 mM	0.0947 mL	0.4736 mL	0.9471 mL	4.7355 mL
100 mM	0.0474 mL	0.2368 mL	0.4736 mL	2.3678 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc