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Antibacterial agent 60

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Catalog No. T38885Cas No. 1426572-68-0

Antibacterial agent 60 is a potent compound that effectively reduces the minimum inhibitory concentration (MIC) of Ceftazidime, an antibacterial agent.

Antibacterial agent 60

Antibacterial agent 60

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Catalog No. T38885Cas No. 1426572-68-0
Antibacterial agent 60 is a potent compound that effectively reduces the minimum inhibitory concentration (MIC) of Ceftazidime, an antibacterial agent.
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
Antibacterial agent 60 is a potent compound that effectively reduces the minimum inhibitory concentration (MIC) of Ceftazidime, an antibacterial agent.
In vitro
Antibacterial agent 60 (example 26) significantly reduces the Minimum Inhibitory Concentration (MIC) values for Ceftazidime, enhancing its antibacterial efficacy against various E. coli strains (MIC=1, 1, 8 mcg/ml for NCTC 1335 1, M50, and 7MP, respectively). Similarly, Antibacterial agent 58 markedly lowers the MIC values of Ceftazidime across different ESBL classes: 0.25-4 mcg/ml for Class A ESBL (E. coli strains W 13353, W3351, and W 13352); 1-8 mcg/ml for Class C ESBL (E. coli strains M 50, 7 MIP, and B 89); 1-4 mcg/ml for KPC ESBL (K. pneumoniae strains H 520, H 521, and H 522); and showing strong activity against Class D ESBL strains A. baumannii 13301 and A. baumannii 13304 with MIC values of 16 and >32 respectively [From WO2013030735A1, example 26].
Chemical Properties
Molecular Weight373.38
FormulaC13H19N5O6S
Cas No.1426572-68-0
Smiles[H][C@]12CN([C@@H](CC1)c1noc(n1)C1CCNCC1)C(=O)N2OS(O)(=O)=O |TLB:21:20:4.5.6:2,7:4:2:18.20|
Relative Density.1.66 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Antibacterial agent 60
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