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Quercetin Dihydrate

Name: Quercetin Dihydrate
Brand: TargetMol
SKU: T6630
Rating: 4.5 (1 reviews)

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Catalog No. T6630Cas No. 6151-25-3

Alias Sophoretin

Quercetin Dihydrate (Sophoretin) is a polyphenolic flavonoid that was found in a wide variety of plant-based foods, such as apples, onions, berries, and red wine. It is used for their nervous system and anticancer effects.

Quercetin Dihydrate

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Purity: 97.77%

Catalog No. T6630Alias SophoretinCas No. 6151-25-3

Pack Size	Price	Availability	Quantity
500 mg	$46	Backorder
1 mL x 10 mM (in DMSO)	$50	Backorder

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Purity:97.77%

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Product Introduction

Bioactivity

Description	Quercetin Dihydrate (Sophoretin) is a polyphenolic flavonoid that was found in a wide variety of plant-based foods, such as apples, onions, berries, and red wine. It is used for their nervous system and anticancer effects.
Targets&IC50	PI3Kδ:3.0 μM (IC50), PI3Kγ:2.4 μM (IC50), PI3Kβ:5.4 μM (IC50)
In vitro	Quercetin, a polyphenolic flavonoid found in a wide variety of plant-based foods, such as apples, onions, berries, and red wine, is utilized in many different cultures for their nervous system and anticancer effects. The pharmacological activities of quercetin that modulate antioxidation/oxidation/kinase-signaling pathways might be differentially elicited in neurons compared with malignant cells, ultimately promoting cell survival or death in a cell type- and metabolism-specific manner. Whereas the broad antioxidation and anti-inflammatory activities of quercetin are important for neuronal survival, the oxidative, kinase- and cell cycle-inhibitory, apoptosis-inducing effects of quercetin are essential for its anticancer effects. [1]
In vivo	LD50: Mice 159 mg/kg (i.g.) [2]
Synonyms	Sophoretin

Chemical Properties

Molecular Weight	338.27
Formula	C₁₅H₁₀O₇·2H₂O
Cas No.	6151-25-3
Smiles	O.O.Oc1cc(O)c2c(c1)oc(-c1ccc(O)c(O)c1)c(O)c2=O
Relative Density.	1.680 g/cm3
Color	Yellow
Appearance	solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: 15 mg/mL (44.34 mM), Sonication is recommended.

DMSO: 45 mg/mL (133.03 mM), Sonication is recommended.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9562 mL	14.7811 mL	29.5622 mL	147.8109 mL
5 mM	0.5912 mL	2.9562 mL	5.9124 mL	29.5622 mL
10 mM	0.2956 mL	1.4781 mL	2.9562 mL	14.7811 mL
20 mM	0.1478 mL	0.7391 mL	1.4781 mL	7.3905 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0591 mL	0.2956 mL	0.5912 mL	2.9562 mL
100 mM	0.0296 mL	0.1478 mL	0.2956 mL	1.4781 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc