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Anti-NLRP3 Antibody (7L984)
😃Good
Catalog No. TMAB-09520
Anti-NLRP3 Antibody (7L984) is a Rabbit antibody targeting NLRP3. Anti-NLRP3 Antibody (7L984) can be used in WB.
Anti-NLRP3 Antibody (7L984)
Anti-NLRP3 Antibody (7L984)
😃Good
Catalog No. TMAB-09520
Anti-NLRP3 Antibody (7L984) is a Rabbit antibody targeting NLRP3. Anti-NLRP3 Antibody (7L984) can be used in WB.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 μL | $148 | 7-10 days | 7-10 days | |
| 50 μL | $264 | 7-10 days | 7-10 days | |
| 100 μL | $472 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-NLRP3 Antibody (7L984) is a Rabbit antibody targeting NLRP3. Anti-NLRP3 Antibody (7L984) can be used in WB. |
| Ig Type | IgG |
| Clone | 7L984 |
| Reactivity | Mouse (predicted:Human,Rat) |
| Application | |
| Recommended Dose | WB=1:500-2000 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Subcellular Localization | Cytoplasm. |
| Tissue Specificity | Expressed in blood leukocytes. Strongly expressed in polymorphonuclear cells and osteoblasts. Undetectable or expressed at a lower magnitude in B- and T-lymphoblasts, respectively. High level of expression detected in chondrocytes. Detected in non-keratinizing epithelia of oropharynx, esophagus and ectocervix and in the urothelial layer of the bladder. |
| Construction | Recombinant Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 10mM phosphate buffered saline (pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol. |
| Research Background | Sensor component of the NLRP3 inflammasome, which mediates inflammasome activation in response to defects in membrane integrity, leading to secretion of inflammatory cytokines IL1B and IL18 and pyroptosis. |
| Immunogen | A synthesized peptide: human NLRP3 |
| Antigen Species | Human |
| Gene Name | NLRP3 |
| Gene ID | |
| Protein Name | NACHT, LRR and PYD domains-containing protein 3 |
| Uniprot ID | |
| Function | May function as an inducer of apoptosis. Interacts selectively with ASC and this complex may function as an upstream activator of NF-kappa-B signaling. Inhibits TNF-alpha induced activation and nuclear translocation of RELA/NF-KB p65. Also inhibits transcriptional activity of RELA. Activates caspase-1 in response to a number of triggers including bacterial or viral infection which leads to processing and release of IL1B and IL18. |
| Molecular Weight | Theoretical: 118 kDa. Actual: 118 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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