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ZINC05007751
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Catalog No. T9880Cas No. 591239-68-8
ZINC05007751 is an effective inhibitor of NIMA-related kinase NEK6 (IC50 = 3.4 μM). ZINC05007751 is very selective against NEK1 and NEK6 with no significant activity observed against NEK2, NEK7, and NEK9.
ZINC05007751
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Purity: 99.7%
Catalog No. T9880Cas No. 591239-68-8
ZINC05007751 is an effective inhibitor of NIMA-related kinase NEK6 (IC50 = 3.4 μM). ZINC05007751 is very selective against NEK1 and NEK6 with no significant activity observed against NEK2, NEK7, and NEK9.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $51 | In Stock | In Stock | |
| 2 mg | $74 | In Stock | In Stock | |
| 5 mg | $122 | In Stock | In Stock | |
| 10 mg | $197 | In Stock | In Stock | |
| 25 mg | $372 | In Stock | In Stock | |
| 50 mg | $597 | In Stock | In Stock | |
| 100 mg | $852 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.7%
Appearance:Solid
Color:Black
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | ZINC05007751 is an effective inhibitor of NIMA-related kinase NEK6 (IC50 = 3.4 μM). ZINC05007751 is very selective against NEK1 and NEK6 with no significant activity observed against NEK2, NEK7, and NEK9. |
| Targets&IC50 | NEK6:3.4 μM |
| In vitro | In ovarian cancer cells PEO1, ZINC05007751 induced perturbation of the cell cycle. ZINC05007751 showed synergism with Cisplatin, resulting in a significant reduction of Cisplatin IC50 from 7.9 to 0.1 µM, with a combination of ZINC05007751 (44 µM) + Cisplatin (10 µM) exhibiting the greatest synergistic effect. ZINC05007751 (6 μM-190 μM; 24 hours) inhibited the growth of MDA-MB-231, PEO1, NCI-H1299, and HCT-15 with IC50 below 100 µM[1]. |
| Molecular Weight | 304.3 |
| Formula | C18H12N2O3 |
| Cas No. | 591239-68-8 |
| Smiles | CC1=C(C#N)C(=O)NC(=O)\C1=C/c1ccc(o1)-c1ccccc1 |
| Relative Density. | no data available |
| Storage | keep away from direct sunlight | Powder: -20°C for 3 years | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 8 mg/mL (26.29 mM), Sonication and heating to 60℃ are recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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