Shopping Cart
  • Remove All
  • TargetMol
    Your shopping cart is currently empty

Anti-Phospho-p53 (Ser46) Polyclonal Antibody

😃Good
Catalog No. TMAC-02999

Anti-Phospho-p53 (Ser46) Polyclonal Antibody is a Rabbit antibody targeting Phospho-p53 (Ser46). Anti-Phospho-p53 (Ser46) Polyclonal Antibody can be used in WB,IF.

Anti-Phospho-p53 (Ser46) Polyclonal Antibody

Anti-Phospho-p53 (Ser46) Polyclonal Antibody

😃Good
Catalog No. TMAC-02999
Anti-Phospho-p53 (Ser46) Polyclonal Antibody is a Rabbit antibody targeting Phospho-p53 (Ser46). Anti-Phospho-p53 (Ser46) Polyclonal Antibody can be used in WB,IF.
Pack SizePriceAvailabilityQuantity
50 μL$2177-10 days
100 μL$3187-10 days
Add to Cart
Add to Quotation
Bulk & Custom
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Questions
View More

Product Introduction

Bioactivity
Description
Anti-Phospho-p53 (Ser46) Polyclonal Antibody is a Rabbit antibody targeting Phospho-p53 (Ser46). Anti-Phospho-p53 (Ser46) Polyclonal Antibody can be used in WB,IF.
Ig Type
IgG
Reactivity
Human
Application
Antibody Type
Polyclonal
Host SpeciesRabbit
ConstructionPolyclonal Antibody
PurificationAntibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
AppearanceLiquid
FormulationSupplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Research Backgroundp53 is a nuclear protein which plays an essential role in the regulation of cell cycle specifically in the transition from G0 to G1. It is found in very low levels in normal cells however in a variety of transformed cell lines in high amounts and believed to contribute to transformation and malignancy. The open reading frame of p53 is 393 amino acids long, with the central region (consisting of amino acids from about 100 to 300) containing the DNA-binding domain. This proteolysis-resistant core is flanked by a C-terminal end mediating oligomerization and an N-terminal end containing a strong transcription activation signal. p53 binds as a tetramer to a PBS (p53-Binding Site) and activates the expression of downstream genes that inhibit growth and/or invasion. p53 binds as a tetramer to a p53-binding site (PBS) and to activate the expression of adjacent genes that inhibit growth and/or invasion. Deletion of one or both p53 alleles reduces the expression of tetramers, resulting in decreased expression of the growth inhibitory genes
Related Conjugates and Formulations
Conjucates
Unconjugated
Others Formats
Phospho
Antigen Details
Immunogen
Peptide sequence around phosphorylation site of serine 46 (M-L-S(p)-P-D) derived from Human p53
Antigen Species
human
Uniprot ID
Chemical Properties
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

Calculator

  • Molarity Calculator
  • Dilution Calculator
  • Reconstitution Calculator
  • Molecular Weight Calculator

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Related Tags: buy Anti-Phospho-p53 (Ser46) Polyclonal Antibody | purchase Anti-Phospho-p53 (Ser46) Polyclonal Antibody | Anti-Phospho-p53 (Ser46) Polyclonal Antibody cost | order Anti-Phospho-p53 (Ser46) Polyclonal Antibody