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Cambendazole

Name: Cambendazole
Brand: TargetMol
SKU: T3361
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3361Cas No. 26097-80-3

Alias Novazole, MK-905, Bonlam

Cambendazole (Novazole) is one of the most effective agents for the therapy of human strongyloidiasis. Cambendazole is a nematocide effective against a variety of gastrointestinal parasites in cattle, sheep, and horses.

Cambendazole

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Purity: 99.61%

Catalog No. T3361Alias Novazole, MK-905, BonlamCas No. 26097-80-3

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$30	In Stock	In Stock
5 mg	$48	In Stock	In Stock
10 mg	$68	In Stock	In Stock
25 mg	$113	In Stock	In Stock
50 mg	$166	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$80	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.61%

Appearance:Solid

Color:White

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COA

Product Introduction

Cambendazole AI Summary

Cambendazole exhibits a range of bioactivities, including a dose-dependent reduction of Nematospiroides dubius in mice. At the highest concentration of 1000 p.p.m., it achieves a 100% reduction in the parasite, with decreasing effectiveness observed at lower concentrations: 80% at 500 p.p.m., 20% at 250 p.p.m., and no reduction at 125 p.p.m. and 62.5 p.p.m. Additionally, Cambendazole inhibits ROR gamma transcriptional activity, demonstrates potency in Schwann cell assays related to PMP22 intronic element and cell viability, affects biochemical firefly luciferase enzyme activity for NPC, induces DNA re-replication in normal breast cells and colon adenocarcinoma cells, inhibits human tyrosyl-DNA phosphodiesterase 1 (TDP1) activity both in the absence and presence of CPT (camptothecin), and shows inhibitory activity against Lassa Virus binding or entry into cells..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Cambendazole (Novazole) is one of the most effective agents for the therapy of human strongyloidiasis. Cambendazole is a nematocide effective against a variety of gastrointestinal parasites in cattle, sheep, and horses.
Synonyms	Novazole, MK-905, Bonlam

Chemical Properties

Molecular Weight	302.35
Formula	C₁₄H₁₄N₄O₂S
Cas No.	26097-80-3
Smiles	N(C(OC(C)C)=O)C=1C=C2C(NC(=N2)C3=CSC=N3)=CC1
Relative Density.	1.4g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 3.03 mg/mL (10.02 mM), Sonication is recommended.

DMSO: 45 mg/mL (148.83 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.61 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3074 mL	16.5371 mL	33.0743 mL	165.3713 mL
5 mM	0.6615 mL	3.3074 mL	6.6149 mL	33.0743 mL
10 mM	0.3307 mL	1.6537 mL	3.3074 mL	16.5371 mL

DMSO

	1mg	5mg	10mg	50mg
20 mM	0.1654 mL	0.8269 mL	1.6537 mL	8.2686 mL
50 mM	0.0661 mL	0.3307 mL	0.6615 mL	3.3074 mL
100 mM	0.0331 mL	0.1654 mL	0.3307 mL	1.6537 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc