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Eperisone hydrochloride

Name: Eperisone hydrochloride
Brand: TargetMol
SKU: T5005
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T5005Cas No. 56839-43-1

Eperisone is a skeletal muscle relaxant and a spasmolytic agent related structurally to Tolperisone.

Eperisone hydrochloride

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Purity: 99.80%

Catalog No. T5005Cas No. 56839-43-1

Eperisone is a skeletal muscle relaxant and a spasmolytic agent related structurally to Tolperisone.

Pack Size	Price	USA Warehouse	Global Warehouse
50 mg	$38	In Stock	In Stock
100 mg	$58	In Stock	In Stock
500 mg	$157	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$30	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.80%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Eperisone hydrochloride AI Summary

Eperisone hydrochloride exhibits diverse bioactivity across several biological functions and virus inhibitions. It demonstrates significant inhibitory effects on human tyrosyl-DNA phosphodiesterase 1 (TDP1) with a potency of approximately 29,000 nM, both alone and in conjunction with CPT. It also possesses antiviral properties against multiple high-impact viruses, inhibiting the binding or entry of Lassa Virus and Marburg Virus with potencies around 31,000 nM and 28,000 nM, respectively. Moreover, it has gametocytocidal activity with a potency of around 25,000 nM and can block the entry of Ebola Virus in various assays, with AC50 values ranging from 10.0 µM to 39.81 µM. Against SARS-CoV-2, Eperisone hydrochloride exhibits multiple antiviral activities. It inhibits virus-induced cytotoxicity in Vero E6 cells with an inhibition index of 1.254 compared to an arbidol control, as well as in Caco-2 cells at a concentration of 10 µM, resulting in a 21.27% inhibition rate after 48 hours. Additionally, it shows 8.445% inhibition of the SARS-CoV-2 3CL-Pro protease at 20 µM concentration, suggesting potential for antiviral drug development. In Vero-6 cells, it results in a minimal inhibition percentage of 0.03% at 10 µM concentration after 48 hours against 0.01 MOI SARS-CoV-2 virus..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Eperisone is a skeletal muscle relaxant and a spasmolytic agent related structurally to Tolperisone.

Chemical Properties

Molecular Weight	295.85
Formula	C₁₇H₂₆ClNO
Cas No.	56839-43-1
Smiles	Cl.CCc1ccc(cc1)C(=O)C(C)CN1CCCCC1
Relative Density.	0.994g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (185.91 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.76 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3801 mL	16.9005 mL	33.8009 mL	169.0046 mL
5 mM	0.6760 mL	3.3801 mL	6.7602 mL	33.8009 mL
10 mM	0.3380 mL	1.6900 mL	3.3801 mL	16.9005 mL
20 mM	0.1690 mL	0.8450 mL	1.6900 mL	8.4502 mL
50 mM	0.0676 mL	0.3380 mL	0.6760 mL	3.3801 mL
100 mM	0.0338 mL	0.1690 mL	0.3380 mL	1.6900 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc