Shopping Cart

Remove All

Your shopping cart is currently empty

Proceed to checkout Continue shopping

NSC 66811

Name: NSC 66811
Brand: TargetMol
SKU: T21578
Rating: 4.5 (1 reviews)

😃Good

Catalog No. T21578Cas No. 6964-62-1

NSC 66811is a novel inhibitor of the murine double minute 2 (MDM2)-p53 interaction. It binds to MDM2 with a Ki of 120 nM and activates p53 in cancer cells with a mechanism of action consistent with targeting the MDM2-p53 interaction.

NSC 66811

😃Good

Catalog No. T21578Cas No. 6964-62-1

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$38	Inquiry	Inquiry
10 mg	$56	Inquiry	Inquiry
25 mg	$92	Inquiry	Inquiry
50 mg	$137	Inquiry	Inquiry
100 mg	$205	Inquiry	Inquiry
200 mg	$298	Inquiry	Inquiry
1 mL x 10 mM (in DMSO)	$42	Inquiry	Inquiry

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Resource Download

Product Introduction

Bioactivity

Description	NSC 66811is a novel inhibitor of the murine double minute 2 (MDM2)-p53 interaction. It binds to MDM2 with a Ki of 120 nM and activates p53 in cancer cells with a mechanism of action consistent with targeting the MDM2-p53 interaction.
Targets&IC50	p53-MDM2:120 nM (ki)
In vitro	Due to the functional activation of p53, NSC 66811 (0, 5, 10, 20 μM) dose-dependently induces the accumulation of p53, MDM2, and p21cip1/waf.

Chemical Properties

Molecular Weight	340.42
Formula	C₂₃H₂₀N₂O
Cas No.	6964-62-1
Smiles	Cc1ccc2ccc(C(Nc3ccccc3)c3ccccc3)c(O)c2n1
Relative Density.	1.235 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 99 mg/mL (290.82 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 3.3 mg/mL (9.69 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9375 mL	14.6877 mL	29.3755 mL	146.8774 mL
5 mM	0.5875 mL	2.9375 mL	5.8751 mL	29.3755 mL
10 mM	0.2938 mL	1.4688 mL	2.9375 mL	14.6877 mL
20 mM	0.1469 mL	0.7344 mL	1.4688 mL	7.3439 mL
50 mM	0.0588 mL	0.2938 mL	0.5875 mL	2.9375 mL
100 mM	0.0294 mL	0.1469 mL	0.2938 mL	1.4688 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc