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Hydroxymethyl dasatinib

Name: Hydroxymethyl dasatinib
Brand: TargetMol
SKU: T86695
Rating: 4.5 (1 reviews)

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Catalog No. T86695Cas No. 910297-58-4

Hydroxymethyl dasatinib (M24) is a benzylhydroxy metabolite of dasatinib that demonstrates potent antiproliferative activity with an IC50 value of 46.7 nM in K562 chronic myeloid leukemia cells, and is used in kinase inhibitor metabolism studies, structure–activity relationship analysis, and evaluation of active drug metabolites in leukemia research.

Hydroxymethyl dasatinib

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Catalog No. T86695Cas No. 910297-58-4

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
10 mg	Inquiry	10-14 weeks	10-14 weeks
50 mg	Inquiry	10-14 weeks	10-14 weeks

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

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Product Introduction

Bioactivity

Description

Chemical Properties

Molecular Weight	504.01
Formula	C₂₂H₂₆ClN₇O₃S
Cas No.	910297-58-4
Smiles	O=C(NC=1C(Cl)=CC=CC1CO)C=2SC(=NC2)NC=3N=C(N=C(C3)N4CCN(CCO)CC4)C

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 100 mg/mL (198.41 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9841 mL	9.9204 mL	19.8409 mL	99.2044 mL
5 mM	0.3968 mL	1.9841 mL	3.9682 mL	19.8409 mL
10 mM	0.1984 mL	0.9920 mL	1.9841 mL	9.9204 mL
20 mM	0.0992 mL	0.4960 mL	0.9920 mL	4.9602 mL
50 mM	0.0397 mL	0.1984 mL	0.3968 mL	1.9841 mL
100 mM	0.0198 mL	0.0992 mL	0.1984 mL	0.9920 mL

Calculator

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Dilution Calculator
Reconstitution Calculator
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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Hydroxymethyl dasatinib

Hydroxymethyl dasatinib

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Product Introduction

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In Vivo Formulation Calculator (Clear solution)

Dose Conversion

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