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Isoetharine mesylate salt

Name: Isoetharine mesylate salt
Brand: TargetMol
SKU: T4983
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T4983Cas No. 7279-75-6

Alias Isoetarine mesilate

Isoetharine mesylate salt (Isoetarine mesilate) is a β-adrenergic receptor agonist. it also is pregnane X receptor (PXR) activator capable of upregulating CYP450 expression.

Isoetharine mesylate salt

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Purity: 99.75%

Catalog No. T4983Alias Isoetarine mesilateCas No. 7279-75-6

Isoetharine mesylate salt (Isoetarine mesilate) is a β-adrenergic receptor agonist. it also is pregnane X receptor (PXR) activator capable of upregulating CYP450 expression.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
10 mg	$29	In Stock	In Stock
25 mg	$48	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.75%

Color:White

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COA HPLC HNMR

Product Introduction

Isoetharine mesylate salt AI Summary

Isoetharine mesylate salt exhibits a diverse range of bioactivities, including significant antiplasmodial activity against various strains of Plasmodium falciparum with IC50 values ranging from 6309.57 nM to 26169.7 nM, indicating potential as an antimalarial agent. Additionally, it demonstrates efficacy in inhibiting SARS-CoV-2 induced cytotoxicity with a low inhibition rate (0.23% to 1.82%) and modest activity against SARS-CoV-2 3CL-Pro protease (10.47% inhibition at 20 µM). Beyond antiviral activities, Isoetharine mesylate salt also modulates Lamin A splicing, inhibits JMJD2E and Tau fibril formation, suppresses human colon tumor cell growth, and targets enzymes like Fructose-1,6-bisphosphate Aldolase and Mammalian Selenoprotein Thioredoxin Reductase 1. It further shows antagonistic activity against several receptors including the Hypoxia Response Element Signaling Pathway, GLP-1, and D3 Dopamine Receptors, while also inhibiting the hERG channel and various other biochemical targets..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Isoetharine mesylate salt (Isoetarine mesilate) is a β-adrenergic receptor agonist. it also is pregnane X receptor (PXR) activator capable of upregulating CYP450 expression.
Synonyms	Isoetarine mesilate

Chemical Properties

Molecular Weight	335.42
Formula	C₁₄H₂₅NO₆S
Cas No.	7279-75-6
Smiles	CS(O)(=O)=O.CCC(NC(C)C)C(O)c1ccc(O)c(O)c1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (163.97 mM), Sonication is recommended.

H2O: 199.7 mM, Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.96 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	2.9813 mL	14.9067 mL	29.8134 mL	149.0668 mL
5 mM	0.5963 mL	2.9813 mL	5.9627 mL	29.8134 mL
10 mM	0.2981 mL	1.4907 mL	2.9813 mL	14.9067 mL
20 mM	0.1491 mL	0.7453 mL	1.4907 mL	7.4533 mL
50 mM	0.0596 mL	0.2981 mL	0.5963 mL	2.9813 mL
100 mM	0.0298 mL	0.1491 mL	0.2981 mL	1.4907 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc