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Anti-GPR44/PTGDR2/CD294 Antibody
🥰Excellent
Catalog No. T9901A-1353
Anti-GPR44/PTGDR2/CD294 Antibody is a humanized monoclonal antibody expressed in CHO cells targeting the GPCR GPR44 (CRTH2/PTGDR2). Featuring a huIgG1 heavy chain and a hukappa light chain, it binds specifically to the extracellular domain of GPR44, blocking the binding of its ligand PGD2. This antagonism inhibits PGD2-induced Gi protein-coupled signaling, restoring intracellular cAMP levels and reducing calcium mobilization, thereby inhibiting the chemotaxis and activation of Th2 cells, eosinophils, and basophils.
Anti-GPR44/PTGDR2/CD294 Antibody
Anti-GPR44/PTGDR2/CD294 Antibody
🥰Excellent
Catalog No. T9901A-1353
Anti-GPR44/PTGDR2/CD294 Antibody is a humanized monoclonal antibody expressed in CHO cells targeting the GPCR GPR44 (CRTH2/PTGDR2). Featuring a huIgG1 heavy chain and a hukappa light chain, it binds specifically to the extracellular domain of GPR44, blocking the binding of its ligand PGD2. This antagonism inhibits PGD2-induced Gi protein-coupled signaling, restoring intracellular cAMP levels and reducing calcium mobilization, thereby inhibiting the chemotaxis and activation of Th2 cells, eosinophils, and basophils.
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| Description | Anti-GPR44/PTGDR2/CD294 Antibody is a humanized monoclonal antibody expressed in CHO cells targeting the GPCR GPR44 (CRTH2/PTGDR2). Featuring a huIgG1 heavy chain and a hukappa light chain, it binds specifically to the extracellular domain of GPR44, blocking the binding of its ligand PGD2. This antagonism inhibits PGD2-induced Gi protein-coupled signaling, restoring intracellular cAMP levels and reducing calcium mobilization, thereby inhibiting the chemotaxis and activation of Th2 cells, eosinophils, and basophils. |
| In vitro | In flow cytometry and biochemical assays, Anti-GPR44/PTGDR2/CD294 Antibody specifically binds to the extracellular N-terminus of GPR44. In functional assays, it antagonizes PGD2-induced Gi signaling with an IC50 of approx. 3.1 nM in cAMP assays and blocks PGD2-mediated calcium mobilization and chemotaxis in receptor-expressing cells [1]. |
| In vivo | In pharmacological studies using mouse models, systemic administration of Anti-GPR44/PTGDR2/CD294 Antibody (at doses such as 10 mg/kg) results in the neutralization of PGD2-induced biological responses. The treatment leads to a significant reduction in the infiltration of inflammatory leukocytes in complex physiological environments [1]. |
| Reactivity | Human |
| Application | FACS Functional assay |
| Antibody Type | Monoclonal |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Uniprot ID | |
| Target | GPR44/PTGDR2/CD294 |
| Isotype | IgG1 |
| Storage | store at low temperature | -20°C for 2 years, 4°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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